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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CO2 laser + HA | Active Comparator | Probands are treated with a CO2 laser. Afterwards a HA gel will be applied. |
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| Thulium laser + HA | Active Comparator | Probands are treated with a thulium laser. Afterwards a HA gel will be applied. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CO2 laser + HA | Other | Probands will be treated with a CO2 laser. Afterwards a HA gel will be applied. To measure microscopic cellular changes, a multiphoton tomography will be used. |
| Measure | Description | Time Frame |
|---|---|---|
| Size of intercellular spaces | Size of intercellular spaces after CO2 or thulium laser treatment compared to control. | 30 minutes and 30 days after treatment. |
| Size of keratinocytes | Size of keratinocytes after CO2 or thulium laser treatment compared to control. | 30 minutes and 30 days after treatment. |
| Size of hyaluronic acid granules | Size of HA granules after CO2 or thulium laser treatment compared to control. | 30 minutes and 30 days after treatment. |
| Distribution of Hyaluronic Acid | Distribution though the epidermal and dermal layers after CO2 or thulium laser treatment compared to control. | 30 minutes and 30 days after treatment. |
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Inclusion Criteria:
- healthy male and female patients
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Medical-Center Hamburg-Eppendorf | Recruiting | Hamburg | 20251 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35837813 | Background | Nguyen L, Mess C, Schneider SW, Huck V, Herberger K. In vivo visualisation of tattoo particles using multiphoton tomography and fluorescence lifetime imaging. Exp Dermatol. 2022 Nov;31(11):1712-1719. doi: 10.1111/exd.14646. Epub 2022 Jul 25. |
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| ID | Term |
|---|---|
| D054020 | Lasers, Gas |
| ID | Term |
|---|---|
| D007834 | Lasers |
| D055096 | Optical Devices |
| D004864 | Equipment and Supplies |
| D055618 | Radiation Equipment and Supplies |
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| Thulium laser + HA | Other | Probands will be treated with a thulium laser. Afterwards a HA gel will be applied. To measure microscopic cellular changes, a multiphoton tomography will be used. |
|