The main endpoint will be to evaluate the efficacy of laser-assisted hyaluronic acid delivery by fractional CO2 laser in facial skin remodeling. The secondary endpoint will be to confirm the safety of this protocol compared to a standard treatment by fractional CO2 laser.

Fractional CO2 lasers are already used in skin remodeling. They can also create vertical channels to enhance topical drug delivery deep into the dermis. Combining the efficacy of fractional CO2 laser to laser-assisted hyaluronic acid delivery has not yet being studied, the combination of these two techniques could improve facial skin remodeling.

The main endpoint will be to evaluate the efficacy of laser-assisted hyaluronic acid delivery by fractional CO2 laser in facial skin remodeling. The secondary endpoint will be to confirm the safety of this protocol compared to a standard treatment by fractional CO2 laser.

Inclusion Criteria:

• Patients admitted to the Laser Center for facial skin remodeling,
• aged from 30 to 70 years old,
• with phototype I to IV (Fitzpatrick scale),
• agreeing to participate in this study, signing the informed consent form
• not fitting in any non-inclusion criterion

Exclusion Criteria:

• Pregnancy or breastfeeding,
• active infection, history of oral or genital herpes
• suspected neoplasia,
• active inflammatory or infectious facial dermatitis,
• oral retinoid treatment in the last 6 months,
• phototype V or VI (Fitzpatrick scale)
• age <30 years or> 70 years,
• patients under guardianship or curatorship,
• hemostasis disorders, thrombolytic or anticoagulant therapy, c
• ongenital methaemoglobinaemia,
• porphyria,
• known hypersensitivity to hyaluronic acid, local anesthetics of the amide group or to any other component of Anesderm cream Ge 5%