This prospective observational case series aims to evaluate the clinical efficacy, safety, and patient satisfaction associated with hyaluronic acid dermal fillers with different degrees of divinyl sulfone (DVS) crosslinking. Twenty adult participants undergoing facial aesthetic treatment will be followed for 90 days. Clinical outcomes will be assessed using three-dimensional imaging (Vectra® 3D), soft tissue ultrasonography, the Global Aesthetic Improvement Scale (GAIS), Net Promoter Score (NPS), Likert satisfaction scales, and standardized adverse event monitoring.
Inclusion Criteria:
Able to undergo standardized photographic documentation, three-dimensional facial imaging (Vectra® 3D), ultrasonography, and patient-reported outcome assessments.
Exclusion Criteria:
Active infection, inflammation, or skin disease at the intended treatment site. Previous facial aesthetic procedure that could interfere with study assessments, according to the investigator's judgment.
Participation in another clinical study that could affect study outcomes. Any medical condition considered by the investigator to make participation unsafe or interfere with study evaluations.
Inability or unwillingness to complete the follow-up schedule or study assessments.
Open-label study. Participants, investigators, and care providers are aware of the intervention administered. Outcome assessments include standardized clinical photographs, Vectra® 3D imaging, ultrasonography, and validated patient-reported outcome measures.
Participants receiving facial treatment with hyaluronic acid dermal fillers with different degrees of divinyl sulfone (DVS) crosslinking according to the clinical indication. Clinical outcomes, safety, and patient satisfaction will be evaluated over a 90-day follow-up period using standardized clinical, imaging, and patient-reported outcome assessments.
Belo Horizonte, Minas Gerais 30493-240, Brazil
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