Relationship Between Acute Phase Markers and Post-operative Pain in Laparoscopic Cholecystectomy: An Observational Study

Relationship Between Acute Phase Markers and Acute Post-operative Pain in Laparoscopic Cholecystectomy: An Observational Study

Many patients undergoing laparoscopic cholecystectomy are prone to developing acute and chronic post-operative pain.

The aim of the study is to show a possible correlation between pain and acute phase proteins in order to:

• predict the severity of pain;
• select most suitable pain relief therapy for the patient.

The day after surgery, some serum markers are determined by a blood sample.

The markers analyzed are:

• Leukocytes;
• C-reactive protein (CRP);
• D-dimer;
• Fibrinogen;
• Neutrophil-to-Lymphocyte Ratio (NLR).

Pain level is assessed using the NRS scale at different times:

• 1st post-operative day;
• 7th post-operative day;
• One month after surgery;
• Three months after surgery;
• Six months after surgery.

Other data collected for the study are: gender, age, BMI.

Inclusion Criteria:

• patient undergoing laparoscopic cholecystectomy

Exclusion Criteria:

• children