From Acute to Chronic Postoperative Pain in Patients for Elective Cholecystectomy. Immunological Tests

From Acute to Chronic Postoperative Pain in Patients for Elective Cholecystectomy. Immunological Tests

Chronic Pain after Cholecystectomy is a well known problem. One theory is that it is due to persisting inflammation.

The purpose of the study is to measure inflammatory factors in cerebrospinal fluid and blod at patients 12 months after the operation.

DNA-samples are collected to examine genetical factors, important for perception of pain, and the development of chronic pain.

Group 1:

Inclusion Criteria:

• Unexplained abdominal pain 12 months after elective cholecystectomy

Exclusion Criteria:

• Immunosuppressive treatment (NSAID excepted)
• Anticoagulant treatment

Group 2:

Inclusion Criteria:

• No pain 12 months after elective cholecystectomy

Exclusion Criteria:

• Immunosuppressive treatment (NSAID excepted)
• Anticoagulant treatment

Group 3:

Inclusion Criteria:

• Elective operation in spinal anesthesia or
• Or healthy volunteers accepting samples of blod, cerebral spinal fluid and saliva, to be collected

Exclusion Criteria:

• Acute or chronic pain condition
• Immunosuppressive treatment (NSAID excepted)
• Previous abdominal operation