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Evaluation of treatment with Coenzyme Q10 and L-Carnitine on Semen Parameters in Infertile men with Idiopathic Oligoasthenoteratospermia
Evaluation of treatment with Coenzyme Q10 and L-Carnitine on Semen Parameters in Infertile men with Idiopathic Oligoasthenoteratospermia a placebo controlled clinical trial
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | Active Comparator | will receive a daily dose of 200 mg of CoQ10 for 3 months |
|
| Group 2 | Active Comparator | will receive L-carnitine 1 tablet per day orally for 3 months |
|
| Group 3 | Active Comparator | will receive combination of a daily dose of 200 mg of CoQ10 and 1 tablet of L-carnitine for 3 months |
|
| Group 4 | Placebo Comparator | will receive a placebo for 3 months |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| co enzyme Q10 , L- Carnitine | Drug | Patient fulfilling inclusion criteria after obtaining consent will be randomized into four equal groups randomization will be computer based |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Semen analysis parameters compared to baseline | Changes in Semen analysis parameters compared to baseline | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Serum hormone levels ([FSH], [LH], testosterone, and prolactin) levels compared to baseline and Cost analysis | Serum hormone levels ([FSH], [LH], testosterone, and prolactin) levels compared to baseline and Cost analysis | 6 moths |
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Inclusion Criteria:
Exclusion Criteria:
o Active genital infections.
semen analysis
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| waleed,mo abdelhamid, ass lecturer | Contact | 01013340534 | wa | drwaleedabdelhamid@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ain Shams University | Recruiting | Cairo | 002 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34070761 | Result | Salvio G, Cutini M, Ciarloni A, Giovannini L, Perrone M, Balercia G. Coenzyme Q10 and Male Infertility: A Systematic Review. Antioxidants (Basel). 2021 May 30;10(6):874. doi: 10.3390/antiox10060874. |
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| ID | Term |
|---|---|
| D009845 | Oligospermia |
| D007246 | Infertility |
| ID | Term |
|---|---|
| D007248 | Infertility, Male |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
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| ID | Term |
|---|---|
| D014451 | Ubiquinone |
| D002331 | Carnitine |
| ID | Term |
|---|---|
| D016227 | Benzoquinones |
| D011809 | Quinones |
| D009930 | Organic Chemicals |
| D003067 | Coenzymes |
| D045762 | Enzymes and Coenzymes |
| D050337 | Trimethyl Ammonium Compounds |
| D000644 | Quaternary Ammonium Compounds |
| D000588 | Amines |
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