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The study was conducted to assess the impact of two doses of coenzyme Q10 on seminal fluid parameters and antioxidant status in infertile men.
The aim of this study was to assess the impact of two doses of coenzyme Q10 on seminal fluid parameters and antioxidant status in infertile men with idiopathic oligoasthenoteratospermia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Coenzyme Q10 200 | Active Comparator | Coenzyme Q10 200mg/day for 3 months |
|
| Coenzyme Q10 400 | Active Comparator | Coenzyme Q10 400mg/day for 3 months |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Coenzyme Q10 200 | Dietary Supplement | Coenzyme Q10 200 mg/day |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Semen volume (WHO 2010 guidelines) | Semen volume in ml | 3 months |
| Sperm concentration in semen (WHO 2010 guidelines) | Sperm concentration in million/ml | 3 months |
| Sperm motility in semen (WHO 2010 guidelines) | Sperm motility (%) | 3 months |
| Sperm morphology in semen (WHO 2010 guidelines) | Normal sperm morphology (%) | 3 months |
| Seminal plasma TAC | Seminal plasma total antioxidant capacity in mmol/ml | 3 months |
| Seminal plasma CAT | Seminal plasma catalase in U/ml | 3 months |
| Seminal plasma SOD | Superoxide dismutase in U/ml | 3 months |
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Inclusion Criteria:
Oligoasthenoteratospermia was diagnosed by semen analysis showing abnormal sperm concentration (<15 million/ml), progressive motility (<32%), total motility (<40%) and morphology (<30% WHO criteria) as defined by WHO manual for semen analysis 2010
Exclusion Criteria:
Male Infertility
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| Name | Affiliation | Role |
|---|---|---|
| Ahmed T Alahmar, MBChB, MSC | University of Sumer, Iraq | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fertility Unit, Babyl | Hillah | 00964 | Iraq |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29984205 | Background | Alahmar AT. The effects of oral antioxidants on the semen of men with idiopathic oligoasthenoteratozoospermia. Clin Exp Reprod Med. 2018 Jun;45(2):57-66. doi: 10.5653/cerm.2018.45.2.57. Epub 2018 Jun 29. | |
| 28771785 | Background | Alshahrani S, Aldossari K, Al-Zahrani J, Gabr AH, Henkel R, Ahmad G. Interpretation of semen analysis using WHO 1999 and WHO 2010 reference values: Abnormal becoming normal. Andrologia. 2018 Mar;50(2). doi: 10.1111/and.12838. Epub 2017 Aug 3. |
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Patients data are anonymous and in hold with the principal investigator
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| ID | Term |
|---|---|
| D007248 | Infertility, Male |
| ID | Term |
|---|---|
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007246 | Infertility |
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Parallel Assignment
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Open Label
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| Coenzyme Q10 400 |
| Dietary Supplement |
Coenzyme Q10 400 mg/day |
|
| 23289958 | Background | Nadjarzadeh A, Shidfar F, Amirjannati N, Vafa MR, Motevalian SA, Gohari MR, Nazeri Kakhki SA, Akhondi MM, Sadeghi MR. Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial. Andrologia. 2014 Mar;46(2):177-83. doi: 10.1111/and.12062. Epub 2013 Jan 7. |
| D052801 |
| Male Urogenital Diseases |