Can we Improve Mortality Prediction in Patients With Sepsis in the Emergency Department

Can we Improve Mortality Prediction in Patients With Sepsis in the Emergency Department

This study aims to identify the prognostic role of procalcitonin (PCT), soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1), the soluble form of the urokinase plasminogen activator receptor (suPAR), highly sensitive C-reactive protein (hs-CRP), Interleukin-6 (IL-6), and azurocidin 1 (AZU1) in 28-day mortality for patients with sepsis in Emergency Department.

The levels of the specified biomarkers were measured upon patient arrival at the Emergency Department (ED) and analyzed their correlation with 28-day mortality. The values of these biomarkers were monitored over the initial three days following admission to the ED, aiming to explore their potential in guiding the de-escalation of antibiotic treatment. Considering their prognostic significance, the main goal is to develop a novel scoring system tailored for use in the emergency department setting.

Inclusion Criteria:

• Sepsis 3 Criteria

Exclusion Criteria:

• individuals aged under 18 or above 90
• pregnant women
• individuals in custody or deprived of their liberty
• patients with associated pathologies such as severe trauma
• other types of shocks
• acute stroke
• burns
• pancreatitis myocardial infarction, pulmonary edema, status asthmatics, convulsions, drug overdose, those requiring emergency surgery
• terminal stage of neoplastic disease