This study aims to evaluate sepsis biomarkers as soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) and soluble urokinase plasminogen activator receptor (sUPAR) in diagnosis of sepsis in comparison to the traditional blood culture and C-reactive protein (CRP) and to evaluate the prognostic value of these biomarkers in comparison to sequential organ failure assessment score (SOFA score), Acute Physiology and Chronic Health Evaluation II ( APACHI score), 28 day mortality.

Sepsis is usually diagnosed in patients have clinically suspected infections with systemic inflammatory response syndrome (SIRS) manifestations. Patients with SIRS as those with trauma or stroke have the same classic infection signs such as fever and elevated leukocytic count, as long as the microbiological diagnosis is the ultimate diagnostic method, but it has poor sensitivity with delayed results. New biomarkers such as sTREM-1 and sUPAR can be used for rapid diagnosis of sepsis and differentiating it from non infectious inflammatory syndromes. Also these soluble biomarkers can be used for predicting the prognosis of sepsis patients

Inclusion Criteria:

• Temperature of >38oC
• Heart rate of >90 beats/min
• Respiratory rate of >20 breaths/min
• Partial pressure of arterial carbon dioxide (PaCO2) of <32 mmHg
• White blood cell (WBC) count of >12,000 cells/mm3

Exclusion Criteria:

• HIV patients
• Patients with neutropenia <1000 cells/mm3
• <18 years of age.

Our study was conducted on patients admitted to different ICUs in Sohag University Hospital who develop possible clinical signs of sepsis