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| Name | Class |
|---|---|
| University of Poitiers | OTHER |
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The main objective is to assess the psycholinguistic and graphomotor characteristics of written production in patients with ASD.
The secondary objectives are:
The primary evaluation criterion is the quantity of written production, namely the number of words produced in 5 minutes on a text copying task (BHK) and in 15 minutes on each of the two written production tasks (descriptive and persuasive).
The secondary evaluation criteria are:
Context :
Autism Spectrum Disorder (ASD) is one of the neurodevelopmental disorders (NDD) characterized by persistent deficits in communication and social interaction, and restricted and repetitive patterns of behavior, interests, and activities (DSM-5 diagnostic criteria; American Psychiatric Association, 2013). These symptoms are present from early developmental stages and correspond to neurological conditions characterized by structural and/or functional brain abnormalities.
While diagnosis is typically made in childhood (average age of 4 years (Rogé, 2019)), many adults seek diagnostic evaluation for ASD from autism resource centers (CRA). This is partly due to the diversity of symptoms that can lead to a 'diagnostic odyssey' spanning several years (Rutherford et al., 2016). Even though the dyad identified by DSM-5 allows for precise diagnosis, many other clinical signs can be found in patients with ASD (mood disorders, sleep disorders, impulsivity/hyperactivity, anxiety, motor disorders, language disorders, etc.), which can complicate diagnosis and delay the implementation of early and appropriate intervention.
In this context, an interesting avenue is the study of writing characteristics in patients with ASD. Indeed, several studies show that patients with ASD present deficits in motor skills as well as in several psycholinguistic domains such as grammar, morphology, and phonology (Habib et al., 2019). Furthermore, individuals with ASD may exhibit specific semantic and pragmatic impairments (Bishop, 1989). These findings may provide additional useful clues in a perspective of differential diagnosis and understanding of cognitive functioning.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental arm : Adults with autism spectrum disorder | Experimental | All of the interventions described below |
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| Control arm : Adults with typical development | Active Comparator | All of the interventions described below |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cognitive and writing tests | Diagnostic Test |
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| Measure | Description | Time Frame |
|---|---|---|
| Assessment of psycholinguistic and graphomotor characteristics of written production in patients with autism spectrum disorder (asd) | Number of words produced in both 3 written production tasks (copy, descriptive text, and persuasive text) : adults with ASD vs adults with typical development | 18 months |
| Measure | Description | Time Frame |
|---|---|---|
| Identifying links between specific deficits of ASD and difficulties in written production | Identifying links between theory of mind (MASC results), which is one of the main explicative model of the autistic functioning, and number of words produced in both 3 written production tasks. Indeed, the writing activity involves taking into account the recipient, and thus the theory of mind. | 18 months |
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Inclusion Criteria for experimental group only:
Inclusion Criteria for both experimental and control groups:
Exclusion Criteria for experimental group only:
Exclusion Criteria for control group only:
- Diagnosis of any NDD (ASD, Attention Deficit Hyperactivity Disorder, Specific Learning Disorder, Language Disorder, Coordination Disorder, Intellectual Disorder)
Exclusion Criteria for both experimental and control groups:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Evan E Launay, Mr | Contact | +33549783846 | evan.launay@ch-niort.fr |
| Name | Affiliation | Role |
|---|---|---|
| Evan E Launay, Mr | Hospital Center of Niort (France) | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier de Niort | Recruiting | Niort | 79000 | France |
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| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| D007802 | Language |
| ID | Term |
|---|---|
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
| D003142 | Communication |
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The study is part of category 2 of research involving humans and which corresponds to an interventional study with minimal risks and constraints. The patient is asked to return to carry out this study.
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| Identifying links between the severity of ASD and difficulties in written production | Identifying links between the severity of ASD (ADOS-2 results) and number of words produced in both 3 written production tasks. Indeed, the severity of ASD can affect the ability to communicate, which is one of the diagnostic criteria of ASD, and thus the ability to produce a text. | 18 months |
| D001519 | Behavior |