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The incidence and prevalence of metabolic risk factors such as obesity, hypertension, diabetes, and dyslipidemia, as well as cardiovascular diseases (CVD), are continuously rising among the occupational population in China, primarily comprising the middle-aged and young adults. Unhealthy lifestyles and declining physical fitness are independent risk factors affecting cardiovascular health. Additionally, the level of physical fitness is influenced by postnatal lifestyles. Lifestyle factors related to cardiovascular health in the occupational population encompass various aspects, including smoking, physical activity, diet, sleep, psychological stress, etc. These factors may interact or have a synergistic effect, necessitating a comprehensive assessment.
This project proposes a prospective cohort study design to establish a monitoring cohort for lifestyle and physical fitness among the occupational population. The study will track and follow individuals with or without any CVD metabolic risk factors, collecting information on general status, lifestyle, physical fitness, and health examination data. Exposure factors such as lifestyle and physical fitness will be measured annually, and the occurrence of CVD-related health outcomes will be observed. The aim is to develop a comprehensive evaluation index for cardiovascular health lifestyle, analyze the direct and indirect impacts of lifestyle and physical fitness on the occurrence and development of CVD, and explore potential mediating and moderating effects of physical fitness in the association between lifestyle and cardiovascular health.
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| Measure | Description | Time Frame |
|---|---|---|
| the composite end point of new major adverse cardiovascular events | including cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization and unstable angina pectoris requiring hospitalization | 10 years |
| Measure | Description | Time Frame |
|---|---|---|
| new incidence of each major adverse cardiovascular events | new incidence of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization, unstable angina requiring hospitalization and other major adverse cardiovascular events | 10 years |
| new incidence of cancer |
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Inclusion Criteria:
Exclusion Criteria:
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occupational person free of cardiovascular disease at baseline in China
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hongyi Du, MD PhD | Contact | 86-10-88396087 | duhy@bjmu.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College | Recruiting | Beijing | Beijing Municipality | China |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
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new incidence of cancer and all-cause death |
| 10 years |
| new incidence of all-cause death | new incidence of all-cause death | 10 years |
| level of systolic pressure | The level of systolic pressure measured at each follow-up evaluation time point | 10 years |
| level of diastolic pressure | The level of diastolic pressure measured at each follow-up evaluation time point | 10 years |
| level of blood lipid | The level of blood lipid measured at each follow-up evaluation time point | 10 years |
| level of BMI | The level of BMI (weight and height will be combined to report BMI in kg/m^2) measured at each follow-up evaluation time point | 10 years |
| level of maximal oxygen uptake (VO2max) | The level of VO2max which is obtained by submaximal exercise testing on cycle ergometer with two-stage workload to assess cardiorespiratory fitness measured at each follow-up evaluation time point | 10 years |
| level of metabolic equivalents (METs) | The level of METs which is obtained by submaximal exercise testing on cycle ergometer with two-stage workload to assess cardiorespiratory fitness measured at each follow-up evaluation time point | 10 years |
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