In this study, Chinese residents aged 35 to 75 years old were recruited from Fujian Province. Physical examination, questionnaire survey and biological sample collection were performed at baseline, and at least 4 years of follow-up were conducted. Information on newly discovered cardiovascular metabolic illnesses and comorbidities was collected during follow-up, and repeated surveys similar to baseline were conducted. To explore the relationship between environment, diet and lifestyle and the risk of cardiovascular metabolic diseases and concomitant disorders.

Inclusion Criteria:

• Aged 35-75, having lived in Fuzhou, Putian, Quanzhou, Nanping, Xiamen, Zhangzhou, Longyan, Sanming, or Ningde in Fujian Province for more than 6 months.

Exclusion Criteria:

• Anyone diagnosed with coronary heart disease, stroke, or cancer.
• Anyone with a severe disability who is unable to participate in the study.

A total of 150,000 adult China aged 35 to 74 who have lived in urban or rural areas of Fuzhou, Putian, Quanzhou, Nanping, Xiamen, Zhangzhou, Longyan, Sanming and Ningde in Fujian Province for more than 6 months without cardiovascular disease history and major disability.