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| ID | Type | Description | Link |
|---|---|---|---|
| KFKT-2025-KY-010 | Other Grant/Funding Number | China Rehabilitation Medicine Association |
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This project intends to conduct a large-sample, prospective, multicenter clinical cohort study in healthy populations. By utilizing a digital cardiopulmonary rehabilitation clinical data research platform, The investigators aim to achieve automated, standardized, and uniform collection, analysis, and AI modeling of large-scale cardiopulmonary exercise testing (CPET) data. The ultimate goals are:
To establish reference standards for cardiopulmonary exercise capacity in the Chinese healthy population.
To develop machine learning-based predictive models for key CPET variables (e.g., peak VO₂) tailored to Chinese demographics.
To compare performance differences between domestically produced and imported CPET devices.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Chinese Age-Sex-Stratified Cardiopulmonary Function Cohort (CACSF Cohort) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cardiopulmonary exercise testing (CPET) | Other | In this study, the cardiopulmonary exercise testing (CPET) system used breath-by-breath continuous analysis for gas exchange and ventilation variables. The protocol included spirometry with an 8-breath data collection method. The cycle ergometer workload ranged from 10 to 40 W/min using a RAMP protocol. The standard CPET protocol comprised a 3-min rest, 3-min warm-up, 8 - 12 min incremental exercise phase, and 3-min each of active and passive recovery. |
| Measure | Description | Time Frame |
|---|---|---|
| Peak Oxygen Uptake | When measuring the peak oxygen uptake of healthy people with a cycle ergometer, first ensure participants are healthy and have signed consent forms. Prepare the cycle ergometer and other equipment, adjusting them to a suitable position. After a 3 - minute warm - up, start the incremental loading test, which lasts 8 - 12 minutes, until termination criteria are met. Record the data, calculate the peak oxygen uptake, and assess the cardiopulmonary function. | On the day of enrollment |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy individuals aged 18 - 65.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Head of Cardiac Rehabilitation Department | Contact | +86 131 8088 9430 | Xiopingmeng@126.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking Union Medical College Hospital | Beijing | Beijing Municipality | 100730 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38942042 | Background | Strain T, Flaxman S, Guthold R, Semenova E, Cowan M, Riley LM, Bull FC, Stevens GA; Country Data Author Group. National, regional, and global trends in insufficient physical activity among adults from 2000 to 2022: a pooled analysis of 507 population-based surveys with 5.7 million participants. Lancet Glob Health. 2024 Aug;12(8):e1232-e1243. doi: 10.1016/S2214-109X(24)00150-5. Epub 2024 Jun 25. | |
| 39537313 |
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all IPD collected throughout the trial, only IPD used in the results publication
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|
| Quanzhou First Hospital Affiliated to Fujian Medical University | Quanzhou | Fujian | 362000 | China |
|
| Guangdong Provincial People's Hospital Affiliated to Southern Medical University | Guangzhou | Guangdong | 510080 | China |
|
| Guangdong Provincial Hospital of Chinese Medicine | Guangzhou | Guangdong | 510120 | China |
|
| Jiangbin Hospital of Guangxi Zhuang Autonomous Region | Nanning | Guangxi | 530021 | China |
|
| Daqing Oilfield General Hospital | Daqing | Heilongjiang | 163000 | China |
|
| The Second Hospital of Harbin Medical University | Harbin | Heilongjiang | 150086 | China |
|
| Anyang Regional Hospital of Puyang City, Henan Province | Puyang | Henan | 457000 | China |
|
| Zhengzhou Central Hospital Affiliated to Zhengzhou University | Zhengzhou | Henan | 450000 | China |
|
| Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | Wuhan | Hubei | 430030 | China |
|
| Xiangya Second Hospital of Central South University | Changsha | Hunan | 410011 | China |
|
| Affiliated Hospital of Changchun University of Chinese Medicine | Changchun | Jilin | 130000 | China |
|
| Qilu Hospital of Shandong University | Jinan | Shangdong | 250012 | China |
|
| Tongji Hospital | Shanghai | Shanghai Municipality | 200065 | China |
|
| First Affiliated Hospital of Xi'an Jiaotong University | Xi’an | Shanxi | 710061 | China |
|
| Background |
| Weeldreyer NR, De Guzman JC, Paterson C, Allen JD, Gaesser GA, Angadi SS. Cardiorespiratory fitness, body mass index and mortality: a systematic review and meta-analysis. Br J Sports Med. 2025 Feb 20;59(5):339-346. doi: 10.1136/bjsports-2024-108748. |
| 40157952 | Background | Wang J, Ren C, Xu S, Yuan Y, Song Y, Xie D, Wang K, Yuan L, Shen T, Xu L, Tang Y, Gao W, Zhao W. A reference equation for peak oxygen uptake for cycle ergometry in Chinese adult participants. Sci Rep. 2025 Mar 29;15(1):10876. doi: 10.1038/s41598-025-94207-7. |
| 39873542 | Background | Brazile TL, Levine BD, Shafer KM. Cardiopulmonary Exercise Testing. NEJM Evid. 2025 Feb;4(2):EVIDra2400390. doi: 10.1056/EVIDra2400390. Epub 2025 Jan 28. |
| 29692203 | Background | Kokkinos P, Kaminsky LA, Arena R, Zhang J, Myers J. A new generalized cycle ergometry equation for predicting maximal oxygen uptake: The Fitness Registry and the Importance of Exercise National Database (FRIEND). Eur J Prev Cardiol. 2018 Jul;25(10):1077-1082. doi: 10.1177/2047487318772667. Epub 2018 Apr 25. |
| 30385268 | Background | Kaminsky LA, Myers J, Arena R. Determining Cardiorespiratory Fitness With Precision: Compendium of Findings From the FRIEND Registry. Prog Cardiovasc Dis. 2019 Jan-Feb;62(1):76-82. doi: 10.1016/j.pcad.2018.10.003. Epub 2018 Oct 30. |
| 28261402 | Background | Daneshvar F, Weinreich M, Daneshvar D, Sperling M, Salmane C, Yacoub H, Gabriels J, McGinn T, Smith MC. Cardiorespiratory Fitness in Internal Medicine Residents: Are Future Physicians Becoming Deconditioned? J Grad Med Educ. 2017 Feb;9(1):97-101. doi: 10.4300/JGME-D-15-00720.1. |
| 29517365 | Background | de Souza E Silva CG, Kaminsky LA, Arena R, Christle JW, Araujo CGS, Lima RM, Ashley EA, Myers J. A reference equation for maximal aerobic power for treadmill and cycle ergometer exercise testing: Analysis from the FRIEND registry. Eur J Prev Cardiol. 2018 May;25(7):742-750. doi: 10.1177/2047487318763958. Epub 2018 Mar 8. |
| 32768174 | Background | Ashikaga K, Itoh H, Maeda T, Itoh H, Ichikawa Y, Tanaka S, Ajisaka R, Koike A, Makita S, Omiya K, Kato Y, Adachi H, Nagayama M, Tajima A, Harada N, Akashi YJ; Committee on Exercise Prescription for Patients (CEPP) Members. Ventilatory efficiency during ramp exercise in relation to age and sex in a healthy Japanese population. J Cardiol. 2021 Jan;77(1):57-64. doi: 10.1016/j.jjcc.2020.07.008. Epub 2020 Aug 5. |
| 33782046 | Background | Katzmarzyk PT, Friedenreich C, Shiroma EJ, Lee IM. Physical inactivity and non-communicable disease burden in low-income, middle-income and high-income countries. Br J Sports Med. 2022 Jan;56(2):101-106. doi: 10.1136/bjsports-2020-103640. Epub 2021 Mar 29. |
| ID | Term |
|---|---|
| D005080 | Exercise Test |
| ID | Term |
|---|---|
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
| D016552 | Ergometry |
| D008919 | Investigative Techniques |
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