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| ID | Type | Description | Link |
|---|---|---|---|
| 2023-A02313-42 | Other Identifier | ID-RCB |
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The age of puberty has fluctuated throughout history. Recent data shows an increase in the age of onset of puberty signs, in the United States but also in Europe. A recent Public Health France study published in 2018 reports an increase in the incidence of precocious puberty with geographical heterogeneity. The consequences of these appearances include the early onset of menarche, short adult height and the psychological impact.
Due to a lack of studies and additional data, the reasons for this development are difficult to understand. Among current hypotheses, the entanglement with the evolution of our environment is at the forefront: the action of environmental endocrine disruptors and nutritional factors could play a role in the process of early appearance of pubertal signs.
The establishment of a national observatory for early and advanced puberty in collaboration with pediatric endocrinologists (on the front line) would allow a reliable and precise field approach, capable of supplementing epidemiological data, which are currently insufficient.
The investigators hypothesize that the establishment of an observatory of pubertal advances (early puberty and advanced puberty) in private medicine is possible, with inclusion of at least 75% of eligible patients, and collection of at least 80% of data.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Precocious puberty group | Girl < 8 years old or boy < 9 years old when the first signs of development appear. | ||
| Advanced puberty group | Girl aged ≥ 8 and < 10 years or boy ≥ 9 and < 11 years old when the first signs of development appear. | ||
| Control group | Boy or girl without any signs of puberty development (Tanner 1) |
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| Measure | Description | Time Frame |
|---|---|---|
| Number of recruited patients with at least 80% of the main data collected | Number of recruited patients with at least 80% of the main data collected (weight, height, BMI, pubertal stage, date of onset of pubertal signs, questionnaires). | Up to 48 month |
| Missing data rate | Missing data rate less than 10% for pubertal stage. | Up to 48 month |
| At least 75% of patients included | At least 75% of patients included compared to the number of eligible patients. | Up to 48 month |
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Inclusion Criteria:
Precocious puberty group (PP) :
Advanced puberty group (AP) :
Control group :
Exclusion Criteria:
All groups
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Patients will be recruited in private heathlcare: 2880 patients distributed between the 2 following groups: PP (Precocious puberty group) and PA (Advanced puberty group), and 480 children in the control group.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Emillie Doye, MD | Contact | 0472118890 | +33 | emilie.doye@chu-lyon.fr |
| Tiphanie GINHOUX | Contact | 0427857723 | 33 | Tiphanie.ginhoux01@chu-lyon.fr |
| Name | Affiliation | Role |
|---|---|---|
| Emillie DOYE, MD | Hospices Civils de Lyon | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinique du Val d'Ouest | Recruiting | Écully | Auvergne-Rhône-Alpes | 69130 | France |
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| ID | Term |
|---|---|
| D011629 | Puberty, Precocious |
| ID | Term |
|---|---|
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |
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| Clinique du Val d'Ouest | Recruiting | Écully | Auvergne-Rhône-Alpes | 69130 | France |
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| Clinique du Val d'Ouest | Recruiting | Écully | Auvergne-Rhône-Alpes | 69130 | France |
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| Pediatric practice | Recruiting | Lyon | Auvergne-Rhône-Alpes | 69006 | France |
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| Pediatric practice | Recruiting | Rennes | Brittany Region | 35200 | France |
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| Pediatric practice | Recruiting | Chambray-lès-Tours | Centre-Val de Loire | 37170 | France |
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| Pediatric practice | Recruiting | Essey-lès-Nancy | Grand Est | 54270 | France |
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| Pediatric practice | Active, not recruiting | Levallois-Perret | Hauts-de-Seine | 92300 | France |
| Pediatric practice | Recruiting | Fondettes | Indre-et-Loire | 37230 | France |
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| Polyclinique Bordeaux rive droite | Active, not recruiting | Lormont | New Aquitaine | 33310 | France |
| Pediatric practice | Recruiting | Pau | New Aquitaine | 64000 | France |
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| Pediatric Practice | Recruiting | Pessac | New Aquitaine | 33600 | France |
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| Clinique rive gauche | Not yet recruiting | Toulouse | Occitanie | 31300 | France |
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| Pediatric practice | Not yet recruiting | Saint-Nazaire | Pays de la Loire Region | 44600 | France |
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| Pediatric practice | Recruiting | Aix-en-Provence | 13090 | France |
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| Hôpital Femme Mère Enfant, Hospices civils de Lyon | Recruiting | Bron | 69677 | France |
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| Pediatric practice | Active, not recruiting | Marseille | 13008 | France |
| Pediatric practice | Recruiting | Marseille | 13012 | France |
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| Pediatric practice | Recruiting | Nice | 06000 | France |
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| Clinique Saint jean | Active, not recruiting | Saint-Jean-de-Védas | 34430 | France |
| Pediatric practice | Recruiting | Trélazé | 49800 | France |
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| Pediatric practice | Recruiting | Paris | Île-de-France Region | 75010 | France |
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| Pediatric practice | Recruiting | Paris | Île-de-France Region | 75011 | France |
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| Pediatric practice | Recruiting | Paris | Île-de-France Region | 75017 | France |
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| Pediatric practice | Active, not recruiting | Paris | Île-de-France Region | 75116 | France |