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GnRH agonists are used in the treatment of precocious puberty in order to improve adult height.However,the psychosocial impact of precocious puberty is often used by the clinician at diagnosis to justify treatment, but can not yet be properly assessed. It can not be considered as a rational neither for the indication to treatment, nor to assess its potential efficacy.
The overall objective of this work is to improve the conditions leading to the therapeutic decision and the procedures for monitoring girls with idiopathic central precocious puberty.
During the day hospital, the diagnostic workup for precocious puberty will be performed and include:
These reviews are conducted as part of usual care and are required to validate the inclusion criteria of patients.
The CBCL questionnaire will be completed by patient's parents and the first semi-structured interview will be conducted by a sociologist assisted by the psychologist, dedicated to the study.
Patient's follow-up will be planned 6 months after inclusion, including similar investigations (except MRI).
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| Measure | Description | Time Frame |
|---|---|---|
| Psychosocial characteristics |
| 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| Child Behavior Checklist | Quantitative data on the psychosocial status of patients will be collected as a self-administered questionnaire: the Child Behavior Checklist (CBCL) that is validated. | 1 day |
| Evolution at 6 months |
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Inclusion Criteria:
6 to 8 years old girls, with idiopathic central precocious puberty defined as:
Parental Informed and written consent
Exclusion Criteria:
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The study will be offered to all children and families who visit in a day hospital in the pediatric endocrinology department of Robert Debré Hospital for further assessment of early puberty.
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| Name | Affiliation | Role |
|---|---|---|
| Dominique SIMON, MD, PhD | Assistance Publique - Hôpitaux de Paris | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Assistance Publique - Hôpitaux de Paris | Paris | Paris | 75019 | France |
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| ID | Term |
|---|---|
| D011629 | Puberty, Precocious |
| ID | Term |
|---|---|
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |
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Changing views of qualitative and quantitative data will be followed six months after the diagnosis of precocious puberty, with or without treatment.
| 6 months |