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Changed to an invitro study using a mechanical lung rather than human subjects.
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Prior to surgery the anesthesia team will be putting a breathing tube into the patient's windpipe and attaching it to a mechanical ventilator (breathing machine). This is to provide oxygen and anesthetic gas, and to help the child breathe while they're asleep. The ventilator also controls the amount of air that moves in and out of the lungs with each breath. This is called tidal volume and that amount is programmed into the machine by the anesthesia team. All of this is standard of care.
As part of the study the investigators will put a small flow sensor between the patient's breathing tube and the tubing from the ventilator. This will measure the amount of air that is moving in and out of the breathing tube. The study team will record the tidal volume that is set on the ventilator and compare it to the airflow measured by the ventilator and the airflow measured by the sensor and see if there is a difference.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mechanical ventilation | Children requiring mechanical ventilation during a surgical procedure. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mechanical ventilation | Procedure | Mechanical ventilation during surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mean inspired tidal volume | The average volume of air moved into the lungs over 25 breaths. | Baseline |
| Mean expired tidal volume | The average volume of air moved out of the lungs over 25 breaths. | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Children requiring intraoperative mechanical ventilation.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nationwide Children's Hospital | Columbus | Ohio | 43205 | United States |
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| ID | Term |
|---|---|
| D012121 | Respiration, Artificial |
| ID | Term |
|---|---|
| D058109 | Airway Management |
| D013812 | Therapeutics |
| D012151 | Resuscitation |
| D004638 | Emergency Treatment |
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| D012138 |
| Respiratory Therapy |