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| Name | Class |
|---|---|
| University of Turku | OTHER |
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The present study aimed to determine the effect of non-surgical periodontal treatment (NSPT) on serum and salivary adipokine and interleukin-1β levels in periodontitis patients with or without type 2 Diabetes Mellitus (T2DM).
The present study aimed to determine the effect of non-surgical periodontal treatment (NSPT) on serum and salivary adipokine and interleukin (IL)-1β levels in periodontitis patients with or without type 2 Diabetes Mellitus (T2DM). A total of 80 patients; 20 healthy, 20 T2DM with periodontitis (P), 20 T2DM periodontally healthy, 20 systemically healthy with P were included in this study. At baseline, serum and saliva samples were collected and the whole mouth clinical periodontal parameters were recorded. Periodontitis patients received NSPT in 4 sessions. Clinical parameters were re-measured and samples were re-collected at 1 and 3 months after treatment. Serum and salivary levels of adipokines and IL-1β were analyzed using a flow cytometry-based technique of Lumina® map™. Data were analyzed using appropriate statistical tests.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No intervention | No Intervention | Periodontally healthy subjects with type 2 diabetes mellitus or systemically healthy didn't have an initial periodontal treatment | |
| Non-surgical periodontal treatment | Experimental | Non-surgical periodontal treatment was performed in a quadrant-wise manner at 1-week intervals for periodontitis patients systemically healthy or with type 2 diabetes mellitus. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Non-surgical periodontal treatment | Procedure | Non-surgical periodontal treatment was performed in a quadrant-wise manner at 1-week intervals. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Serum and Salivary Resistin Levels (pg/ml) | Serum and salivary resistin levels | Change between baseline, 1 and 3 months after non-surgical periodontal treatment |
| Serum and Salivary Leptin Levels (pg/ml) | Serum and salivary leptin levels | Change baseline, 1 and 3 months after non-surgical periodontal treatment |
| Serum and Salivary Visfatin Levels (pg/ml) | Serum and salivary visfatin levels | Change baseline, 1 and 3 months after non-surgical periodontal treatment |
| Serum and saliva IL-1β levels (pg/ml) | Serum and salivary IL-1β levels | Change baseline, 1 and 3 months after non-surgical periodontal treatment |
| Measure | Description | Time Frame |
|---|---|---|
| HbA1c ( %) | Glycated Hemoglobin Level % | Change baseline, 1 and 3 months after non-surgical periodontal treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Probing Depth (mm) | probing depth measured from the gingival margin seldom corresponds to sulcus or pocket depth in mm. | Change baseline, 1 and 3 months after non-surgical periodontal treatment |
| Plaque Index |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Basak Dogan, Prof. Dr. | Department of Periodontology, Faculty of Dentistry, Marmara University | Study Director |
| Yaprak Kalkan, Dt. | Department of Periodontology, Institute of Health Sciences, Marmara University | Principal Investigator |
| Ulvi Kahraman Gürsoy, Assoc. Prof. | Department of Periodontology, Institute of Dentistry, Turku University | Study Chair |
| Mervi Gürsoy, Assoc. Prof. | Department of Periodontology, Institute of Dentistry, Turku University | Study Chair |
| Eija Könönen, Prof. Dr. | Department of Periodontology, Institute of Dentistry, Turku University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Periodontology, Institute of Dentistry, Turku University | Turku | Lemminkäisenkatu 2 | FI-20520 | Finland | ||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18565135 | Background | Furugen R, Hayashida H, Yamaguchi N, Yoshihara A, Ogawa H, Miyazaki H, Saito T. The relationship between periodontal condition and serum levels of resistin and adiponectin in elderly Japanese. J Periodontal Res. 2008 Oct;43(5):556-62. doi: 10.1111/j.1600-0765.2008.01085.x. Epub 2008 Jun 28. | |
| 23805816 | Background |
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| ID | Term |
|---|---|
| D010518 | Periodontitis |
| D003924 | Diabetes Mellitus, Type 2 |
| D003920 | Diabetes Mellitus |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D044882 | Glucose Metabolism Disorders |
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The measurement of the state of oral hygiene by Silness-Löe plaque index is based on recording both soft debris and mineralized deposits on the following teeth. Values 0,1,2 and 3 can be taken. While 0 indicates the least value, 3 indicates the maximum value.
| Change baseline, 1 and 3 months after non-surgical periodontal treatment |
| Gingival Index | A measure of periodontal disease based on the severity and location of the lesion. Values 0,1,2 and 3 can be taken. While 0 indicates the least value, 3 indicates the maximum value. | Change baseline, 1 and 3 months after non-surgical periodontal treatment |
| Bleeding on Probing (%) | Percentage of bleeding sites. Bleeding on probing, often abbreviated BOP, is a sign of inflammation and indicates some sort of destruction and erosion to the lining of the sulcus or the ulceration of sulcular epithelium. The blood comes from lamina propria after the ulceration of the lining. | Change baseline, 1 and 3 months after non-surgical periodontal treatment |
| Clinical Attachment Level (mm) | The estimated position of structures that support the tooth as measured with a periodontal probe in mm; provides an estimate of a tooth's stability and of loss of bone support. | Change baseline, 1 and 3 months after non-surgical periodontal treatment |
| Marmara University, Faculty of Dentistry, Department of Periodontology |
| Istanbul |
| Maltepe |
| 34854 |
| Turkey (Türkiye) |
| Gokhale NH, Acharya AB, Patil VS, Trivedi DJ, Setty S, Thakur SL. Resistin levels in gingival crevicular fluid of patients with chronic periodontitis and type 2 diabetes mellitus. J Periodontol. 2014 Apr;85(4):610-7. doi: 10.1902/jop.2013.130092. Epub 2013 Jun 27. |
| 25858047 | Background | Goncalves TE, Zimmermann GS, Figueiredo LC, Souza Mde C, da Cruz DF, Bastos MF, da Silva HD, Duarte PM. Local and serum levels of adipokines in patients with obesity after periodontal therapy: one-year follow-up. J Clin Periodontol. 2015 May;42(5):431-9. doi: 10.1111/jcpe.12396. Epub 2015 Apr 30. |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |