Leptin and Visfatin in Diabetic Patients With Periodontitis Before and After Periodontal Therapy

Effect of Non-surgical Periodontal Therapy on Leptin and Visfatin Expression in Gingival Tissues of Chronic Periodontitis With and Without Type 2 Diabetes Mellitus: A Study Utilizing ELISA and Real Time PCR

1. Are adipokines involved in pathogenesis of periodontal disease in diabetic patients?
2. Does their level change after periodontal therapy?

Patients with chronic periodontitis only and patients with chronic periodontitis and diabetes were evaluated for levels of leptin and visfatin in the gingival tissues before and after non-surgical periodontal therapy.

Inclusion Criteria:

• diabetic patients having diabetes mellitus ≥5 years prior to the study.
• chronic periodontitis with clinical attachment loss > 5 mm.
• otherwise systemically healthy subjects.

Exclusion Criteria:

• any known systemic diseases other than diabetes.
• pregnancy or lactation.
• smokers.
• receiving periodontal treatment in the last 6 months.
• taking any drugs or medications other than anti-diabetic drugs.