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The aim of this study is to evaluate the relationship between disease severity and subcutaneous tissue shearwave elastography findings with pain threshold and quality of life in patients diagnosed with lipedema.
Patients diagnosed with lipedema were divided into 3 stages according to disease severity. Pain level was evaluated with visual analogue scale, pain threshold with algometric measurement, and quality of life with EQ-5D general quality of life scale. All patients underwent measurements using B-mode ultrasound and subcutaneous elastic modulus with shear wave elastography (SWE) imaging of lower limbs at three anatomical levels.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stage 1 lipedema patients | It is the stage where normal skin surface, enlarged subcutaneous fat tissue, and many small nodules are present upon palpation. |
| |
| Stage 2 lipedema patients | It is the stage with rough skin surface, large nodules of palpable subcutaneous fat tissue |
| |
| Stage 3 lipedema patients | It is the stage in which lobular deformation of the skin surface occurs with enlarged fatty tissue. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SWE:B-mode ultrasound and subcutaneous elastic modulus with shear wave elastography at three level | Diagnostic Test | Visual analog scale(VAS):This scale measure in which individuals rate their pain from 0 to 10, with 0 indicating no pain at all and 10 representing the worst pain;pain threshold through algometric measurement; quality of life using the EQ-5D general quality of life scale. |
| Measure | Description | Time Frame |
|---|---|---|
| Subcutaneous elastic modulus with shear wave elastography (SWE) imaging of lower limbs | Measurements using B-mode ultrasound and subcutaneous elastic modulus with shear wave elastography (SWE) imaging of lower limbs at three anatomical levels. | 1 day |
| Visual analog scale(VAS) | Pain levels were assessed using the visual analog scale(VAS) | 1 day |
| Algometric measurement | Pain threshold through algometric measurement | 1 day |
| EQ-5D general quality of life scale. | quality of life using the EQ-5D general quality of life scale. | 1 day |
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Inclusion Criteria:
Exclusion Criteria:
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The study consist of female patients aged 18-70, diagnosed with lipedema
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gulcan Ozturk | Istanbul | 34752 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35972618 | Background | Clarke C, Kirby JN, Smidt T, Best T. Stages of lipoedema: experiences of physical and mental health and health care. Qual Life Res. 2023 Jan;32(1):127-137. doi: 10.1007/s11136-022-03216-w. Epub 2022 Aug 16. | |
| 34764426 | Background | Ishaq M, Bandara N, Morgan S, Nowell C, Mehdi AM, Lyu R, McCarthy D, Anderson D, Creek DJ, Achen MG, Shayan R, Karnezis T. Key signaling networks are dysregulated in patients with the adipose tissue disorder, lipedema. Int J Obes (Lond). 2022 Mar;46(3):502-514. doi: 10.1038/s41366-021-01002-1. Epub 2021 Nov 11. |
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| 31544340 | Background | Buso G, Depairon M, Tomson D, Raffoul W, Vettor R, Mazzolai L. Lipedema: A Call to Action! Obesity (Silver Spring). 2019 Oct;27(10):1567-1576. doi: 10.1002/oby.22597. |
| ID | Term |
|---|---|
| D010146 | Pain |
| D065134 | Lipedema |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| ID | Term |
|---|---|
| D064232 | Visual Analog Scale |
| ID | Term |
|---|---|
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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