This study aimed to compare the efficacy of lidocaine spray (S) alone versus lidocaine spray combined with lidocaine viscous solution (S+V) in facilitating pharyngeal observation during Non-sedating upper gastrointestinal endoscopy (UGE).

A randomized controlled trial was conducted between July and October 2023 at Sawanpracharak hospital, Thailand. Of 250 patients undergoing UGE, 125 were randomly assigned to group S (lidocaine spray alone) and 125 to group S+V (lidocaine spray plus lidocaine viscous solution). The total dose of lidocaine did not exceed 5 mg/kg in both groups

Inclusion Criteria:

• Patients scheduled for upper gastrointestinal endoscopy:
• Patients who are robust, without chronic illnesses, or with controlled chronic conditions that do not adversely affect the function of any organ (American Society of Anesthesiologists (ASA) physical status classification I-II).

Exclusion Criteria:

• Has a history of receiving painkillers or sleeping pills within 24 hours before the endoscopy.
• Has a history of post-endoscopy nausea and vomiting.
• Patients who have undergone upper gastrointestinal endoscopy previously.
• Has chronic conditions such as epilepsy, vertigo, or mental health disorders.
• Has a history of allergy to anesthesia used in the study.
• Pregnant or currently breastfeeding.
• Refuses to participate in the study.