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Intravenous infusion of lidocaine significantly reduces incidence of bucking when perfomed gastroscopy.
This study divide patients into two groups, the patients in lidocaine group will be given lidocaine; the control group will be given placebo .the primary endopiont was to investigate whether intravenous lidocaine can reduce incidence of bucking and movement in sedation of gastroscopy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control group | Placebo Comparator | the control group will be given the same volume of saline as the experimental group |
|
| lidocaine group | Experimental | the experimental group will be given l-1.5mg lidocaine and then 2mg/kg/h |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| placebo | Drug | the control group will be given the same volume of saline. |
|
| Measure | Description | Time Frame |
|---|---|---|
| the incidence of bucking during the procedure | the difference between incidence of bucking of the two groups | half a year |
| Measure | Description | Time Frame |
|---|---|---|
| propofol consumption difference between the two groups | the total propofol dosage consumption between the two groups | half a year |
| the incidence of infusion pain when adminstrated propofol | the infusion pain devied into no pain, mild pian, and severe pain |
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Inclusion Criteria:
patients aged >18 years who were scheduled for ERCP at Qilu hospital.
Exclusion Criteria:
patients with ASA (American Society of Anesthesiologists) Class 4 or 5, pre-existing hypoxemia (SpO2 <90%), hypotension (systolic blood pressure <90 mm Hg), bradycardia (HR<50 beats/min), uncontrolled hypertension (SBP >170 mm Hg, diastolic blood pressure>100 mm Hg), severe renal or liver failure, pregnancy or lactation, allergy to lidocaine, atrioventricular block, epilepsy, and inability to give informed consen
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| jing Liu | Contact | +86-18560083755 | liujingqilu@126.com | |
| yanqing li | Contact | 86-531-82169236 | liyanqing@sdu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Shan dong China | Qilu Hospital of Shandong University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Gastroenterology, Qilu Hospital, Shandong University | Recruiting | Jinan | Shandong | 250012 | China |
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| ID | Term |
|---|---|
| D012965 | Sodium Chloride |
| D008012 | Lidocaine |
| ID | Term |
|---|---|
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
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Participants are randomly assigned to controll group or lidocaine group. Participants of control group are given placebo while participants of lidocaine group are given lidocaine.
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| Lidocaine | Drug | the experimental group will be given 1-1.5mg/kg lidocaine and then 2mg/kg/h |
|
|
| half a year |
| Safety assessed by the rate of hypoxia during the procedure | Hypoxia, defined as peripheral oxygen saturation <90% for >30 seconds | half a year |
| Safety assessed by the rate of hypotention during the procedure | Hypotension, defined as systolic blood pressure <90 mmHg | half a year |
| Safety assessed by the rate of breadycardia during the procedure | Bradycardia, defined as heart rate <50 beats/min | half a year |
| Safety assessed by the rate of required airway management during the procedure | Required airway management such as jaw lifting, mask ventilation, or tracheal intubation in severe hypoxia Required airway management such as jaw lifting, mask ventilation, or tracheal intubation in severe hypoxia | half a year |
| endoscopists satisfaction assessed by the performer | the endoscopists satisfacition score were assessed on a 0-10VAS after the procedure | half a year |
| patient satisfaction assessed by the patient | the patient satisfacition score were assessed on a 0-10VAS 30mins after the procedure | half a year |
| anesthetist satisfaction | the anesthetist satisfacition score were assessed on a 0-10VAS 30mins after the procedure | half a year |
| pain socre after the gastroscopy | pain were measured on a 0-10VAS at arrival in the recovery room ,30min later | half a year |
| fatigue score after the ERCP | fatigue were measured on a 0-10VAS at arrival in the recovery room ,30min later | half a year |
| D017670 |
| Sodium Compounds |
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |