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intravenous infusion of lidocaine significantly reduce fatigue and pain and improve the patients satisfaction after sedation for colonoscopy.
This study divide patients into two groups, lidocaine group one will be given lidocaine intravenously; control group will be given saline . the difference between patients fatigue and pain will be compared. and the propofol consumption, pain after infusion of propofol, patients, endoscopists and anaesthesist satifaction, the incidence of hypotenstion, hypoxia, and bradycardia will aslo be compared between the two groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control group | Placebo Comparator | the control group will be given the same volume of saline as the experimental group |
|
| lidocaine group | Experimental | the experimental group will be given l-1.5mg lidocaine and then 2mg/kg/h |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| placebo | Drug | the control group will be given the same volume of saline. |
|
| Measure | Description | Time Frame |
|---|---|---|
| fatigue score after colonoscopy | fatigue were measured on a 0-10VAS at arrival in the recovery room ,30min later | half a year |
| Measure | Description | Time Frame |
|---|---|---|
| pain socre after colonoscopy | pain were measured on a 0-10VAS at arrival in the recovery room ,30min later | half a year |
| Measure | Description | Time Frame |
|---|---|---|
| infusion pain when adminstrate propofol | infusion pain was divided into no pain, mide pain and severe pain | half a year |
| Safety assessed by the rate of hypoxia during the procedure Safety assessed by the rate of hypoxia during the procedure |
Inclusion Criteria:
Inclusion Criteria: patients aged >18 years who were scheduled for colonscopy at Qilu hospital.
Exclusion Criteria:patients with ASA (American Society of Anesthesiologists) Class 4 or 5, pre-existing hypoxemia (SpO2 <90%), hypotension (systolic blood pressure <90 mm Hg), bradycardia (HR<50 beats/min), uncontrolled hypertension (SBP >170 mm Hg, diastolic blood pressure>100 mm Hg), severe renal or liver failure, pregnancy or lactation, allergy to lidocaine, atrioventricular block, epilepsy, and inability to give informed consen
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jing Liu, MD | Contact | +86-18560083755 | liujingqilu@126.com | |
| yanqing li, phD | Contact | 86-531-82169236 | liyanqing@sdu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Shan dong China | Qilu Hospital of Shandong University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Gastroenterology, Qilu Hospital, Shandong University | Recruiting | Jinan | Shandong | 250012 | China |
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| ID | Term |
|---|---|
| D012965 | Sodium Chloride |
| D008012 | Lidocaine |
| ID | Term |
|---|---|
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
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Participants are randomly assigned to controll group or lidocaine group. Participants of control group are given placebo while participants of lidocaine group are given lidocaine.
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| lidocaine | Drug | the experimental group will be given 1-1.5mg/kg lidocaine and then 2mg/kg/h |
|
|
Hypoxia, defined as peripheral oxygen saturation <90% for >10 seconds
| half a year |
| Safety assessed by the rate of hypotention during the procedure | Hypotension, defined as systolic blood pressure <90 mmHg | half a year |
| Safety assessed by the rate of breadycardia during the procedure | Bradycardia, defined as heart rate <50 beats/min | half a year |
| Safety assessed by the rate of required airway management during the procedure | Required airway management such as jaw lifting, mask ventilation, or tracheal intubation in severe hypoxia Required airway management such as jaw lifting, mask ventilation, or tracheal intubation in severe hypoxia | half a year |
| Safety assessed by the rate of involuntary movement | Involuntary movements, defined as unconscious movements requiring restraint or severe limb movement | half a year |
| endoscopists satisfaction assessed by the performer | the endoscopists satisfacition score were assessed on a 0-10VAS after the procedure | half a year |
| patient satisfaction assessed by the patient | the patient satisfacition score were assessed on a 0-10VAS 30mins after the procedure | half a year |
| anesthetist satisfaction assessed by the anesthestist | the anesthetist satisfacition score were assessed on a 0-10VAS after the procedure | half a year |
| D017670 |
| Sodium Compounds |
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |