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The study aims to carry out a translational analysis of the microbiome and metabolomics in patients suffering from non-obstructive azoospermia, with the aim of investigating prognostic factors predictive of the possible finding of spermatozoa following testicular pulp extraction and differences in blood and seminal level with the fertile population to identify etiopathogenic pathways of this condition.
The study aims to carry out a translational analysis of the microbiome and metabolomics in patients suffering from non-obstructive azoospermia, with the aim of investigating prognostic factors predictive of the possible finding of spermatozoa following testicular pulp extraction and differences in blood and seminal level with the fertile population to identify etiopathogenic pathways of this condition.
Furthermore, the study aims to assess if the blood and seminal alterations of infertile patients have similarities with the same fluids of elderly patients, validating from a metabolomic and microbiomic point of view the hypothesis of premature aging of infertile patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Infertile men | Patients diagnosed with idiopathic non-obstructive azoospermia |
| |
| Fertile men | fertile subjects (pregnancy within 12 months of the start of the research by the couple, according to WHO 2010 criteria) |
| |
| Old fertile men | Subjects known to have been fertile subjects (pregnancy within 12 months of the start of the research by the couple, according to WHO 2010 criteria) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Analysis of microbiome and metabolomics | Other | Analysis of microbiome and metabolomics through the assessment of blood and semen parameters |
|
| Measure | Description | Time Frame |
|---|---|---|
| Prognostic role of the blood and semen samples | Metabolomics and microbiome signature fertile and infertile men predicting possible finding of spermatozoa | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Andrea Salonia, MD | Contact | 02 2643 5661 | salonia.andrea@hsr.it | |
| Alessia d'Arma, MSc | Contact | 02 2643 5506 | darma.alessia@hsr.it |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IRCCS Ospedale San Raffaele | Recruiting | Milan | Lombardy | 20132 | Italy |
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| ID | Term |
|---|---|
| C564665 | Azoospermia, Nonobstructive |
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