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| Name | Class |
|---|---|
| URC-CIC Paris Descartes Necker Cochin | OTHER |
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Multidisciplinary, multicentric, cross-sectional study on men in infertile couples who conduct their sperm test through their diagnosis of infertility
Assessment of sperm parameters and metabolic syndrome relations in men attending a Reproductive Biomedicine centre for an infertility of their couple.
Secondary objectives are to study relationship between sperm parameters and:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Infertile men | Man partner of an infertile couple. Blood sample, sperm sample and clinical examens will be done at the day of the inclusion |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood sample, sperm sample and clinical examens | Other | Blood sample, sperm sample and clinical examens will be done at the day of the inclusion |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of spermatozoid and their relation with syndrome metabolic parameters | We will measure the parameters of metabolic syndrome (triglycerides, HDL and LDL cholesterol, systolic and diastolic blood pressure, fasting glucose) and correlate them with the number of spermatozoid . | Day 0 |
| Measure | Description | Time Frame |
|---|---|---|
| Relationship between spermogram and spermocytogram and other metabolic parameters | Relationship between other spermogram/spermocytogram and metabolic markers (biomarkers and anthropometric adiposity and insulin resistance) | Day 0 |
| Environmental parameters |
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Inclusion Criteria:
Exclusion Criteria:
patient with problems understanding French
patient smoking more than two-pack-a-day
patient monitoring for viral risk.
man with an unidiopathic infertility which may be explained by:
1) identifiable factors in direct questioning at the sperm analysis:
exposure to toxic products
infectious disease history
pathological anatomical background 2) factors identified at the etiologic investigation: cytogenetic and genetic
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Man consulting for primary or secondary infertility, with or without earlier notion of paternity
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| Name | Affiliation | Role |
|---|---|---|
| Rachel Lévy, MD, PhD | Tenon Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jean Verdier Hospital | Bondy | 93140 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23242914 | Background | Sermondade N, Faure C, Fezeu L, Shayeb AG, Bonde JP, Jensen TK, Van Wely M, Cao J, Martini AC, Eskandar M, Chavarro JE, Koloszar S, Twigt JM, Ramlau-Hansen CH, Borges E Jr, Lotti F, Steegers-Theunissen RP, Zorn B, Polotsky AJ, La Vignera S, Eskenazi B, Tremellen K, Magnusdottir EV, Fejes I, Hercberg S, Levy R, Czernichow S. BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Hum Reprod Update. 2013 May-Jun;19(3):221-31. doi: 10.1093/humupd/dms050. Epub 2012 Dec 12. | |
| 18929048 |
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| ID | Term |
|---|---|
| D007248 | Infertility, Male |
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007246 | Infertility |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Blood and sperm samples will be collected from all patients BLOOD :Whole blood was collected on dry, heparin or EDTA tubes. After several soft turnings, tubes were centrifuged at 1900g for 10min.Then plasma, serum, buffy coat or red blood cells were taken in microtubes and frozen at -80°C.
SPERM: After liquefaction, total sperm was centrifuged at 600g for 10min. Seminal plasma was collected directly on microtubes and stored at -80°C. After trypsinisation, spermatozoa were fixed in Carnoy solution and stored at -20°C.
DNA was separated from buffy coat using DNA extract kit
Evaluation of environmental parameters (physical activity, tobacco consumption, quality of life) by classical questionnaire |
| Day 0 |
| Relationship between spermogram and spermocytogram and other metabolic parameters | Relationship between other spermogram/spermocytogram and markers of inflammation | Day 0 |
| Relationship between spermogram and spermocytogram and other metabolic parameters | Relationship between other spermogram/spermocytogram and markers of oxidative stress (plasma, seminal genetic polymorphisms involved in oxidative stress, genetic analyzes of sperm) | Day 0 |
| Relationship between spermogram and spermocytogram and other metabolic parameters | Relationship between other spermogram/spermocytogram and hormonal markers | Day 0 |
| Relationship between spermogram and spermocytogram and other metabolic parameters | Relationship between other spermogram/spermocytogram and innovative settings (studies epigenetic finger length and width of the wrist) | Day 0 |
| Background |
| Hammoud AO, Gibson M, Peterson CM, Meikle AW, Carrell DT. Impact of male obesity on infertility: a critical review of the current literature. Fertil Steril. 2008 Oct;90(4):897-904. doi: 10.1016/j.fertnstert.2008.08.026. |
| 22412113 | Background | Sermondade N, Faure C, Fezeu L, Levy R, Czernichow S; Obesity-Fertility Collaborative Group. Obesity and increased risk for oligozoospermia and azoospermia. Arch Intern Med. 2012 Mar 12;172(5):440-442. doi: 10.1001/archinternmed.2011.1382. |
| 22999785 | Background | Michalakis K, Mintziori G, Kaprara A, Tarlatzis BC, Goulis DG. The complex interaction between obesity, metabolic syndrome and reproductive axis: a narrative review. Metabolism. 2013 Apr;62(4):457-78. doi: 10.1016/j.metabol.2012.08.012. Epub 2012 Sep 20. |
| 31115360 | Result | Bongrani A, Elfassy Y, Brun JS, Rame C, Mellouk N, Fellahi S, Bastard JP, Levy R, Vasseur C, Froment P, Dupont J. Expression of adipokines in seminal fluid of men of normal weight. Asian J Androl. 2019 Sep-Oct;21(5):528-530. doi: 10.4103/aja.aja_25_19. No abstract available. |
| 31705791 | Result | Elfassy Y, Bongrani A, Levy P, Foissac F, Fellahi S, Faure C, McAvoy C, Capeau J, Dupont J, Feve B, Levy R, Bastard JP; Metasperme group. Relationships between metabolic status, seminal adipokines, and reproductive functions in men from infertile couples. Eur J Endocrinol. 2020 Jan;182(1):67-77. doi: 10.1530/EJE-19-0615. |
| 35668388 | Derived | Saget S, Kappeler L, Grandjean V, Leneuve P, Berthaut I, Faure C, Czernichow S, Racine C, Levy R, Dupont C; Metasperme Collaboratif group. Association between metabolic disorders and seminal plasma miRNA levels: a pilot study. Basic Clin Androl. 2022 Jun 7;32(1):9. doi: 10.1186/s12610-022-00159-7. |
| D052801 |
| Male Urogenital Diseases |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |