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| ID | Type | Description | Link |
|---|---|---|---|
| 2023-A01688-37 | Other Identifier | IDRCB |
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| Name | Class |
|---|---|
| Infectious Diseases Models for Innovative Therapies center | UNKNOWN |
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Acute bronchiolitis is a common disease in children under the age of two, caused mainly by the respiratory syncytial virus (RSV). Furthermore, given the same medical history, it is still very difficult to predict the course and severity of the infection at the onset of symptoms, Some studies have highlighted the importance of the microbiota (intestinal, oral or nasopharyngeal) and of the immune response to RSV in children, We will include 80 children under 2 years old with hospitalized bronchiolitis and non-hospitalized bronchiolitis. Oral, nasal and stool samples will be taken to study the various microbiota in search of dysbiosis. A capillary blood sample will be taken for immune studies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Severe bronchiolitis | venous blood samples. Buccal, nasopharyngeal and rectal swabs |
| |
| Non-hospitalized bronchiolitis | Capillary blood samples. Buccal, nasopharyngeal and rectal swabs |
| |
| Bronchiolitis ihospitalized in ICU | Capillary blood samples. Buccal, nasopharyngeal and rectal swabs |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sampling | Other | Single-time sampling of respiratory virus-infected children |
|
| Measure | Description | Time Frame |
|---|---|---|
| Dysbiosis | comparison of the quantitative and qualitative composition of bacteria (alpha diversity, beta diversity, Shannon and Simpson index) in the digestive and nasopharyngeal microbiota | Inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of innate and adaptive responses by quantification of cytokines and chemokines in plasma | Inflammatory/regulatory cytokines (IL1->17, IL-10, TGF-b, EGF, FGF-2, IFN-alpha, IFN-gamma, IFN-beta, MCRP-1 MCP-3, TNF-alpha...), cytokines of adaptative response (Th1, Th17, Th2 and/or Treg), markers of inflammatory response (interferon, TNFa, …), quantified by Luminex | inclusion |
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Inclusion Criteria:
Exclusion Criteria:
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Bronchiolitis in patient under 12 months old
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Etienne BIZOT, Doctor | Contact | 33145374618 | etienne.bizot@aphp.fr |
| Name | Affiliation | Role |
|---|---|---|
| Etienne BIZOT, Doctor | AP-HP Hôpital Antoine Beclere | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| APHP, Antoine Béclère Hospital | Recruiting | Clamart | 92140 | France |
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| ID | Term |
|---|---|
| D001988 | Bronchiolitis |
| D064806 | Dysbiosis |
| ID | Term |
|---|---|
| D001991 | Bronchitis |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D001982 | Bronchial Diseases |
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| Identifying the mRNA profile in blood samples and nasal swabs | mRNA will be identified by using RNA-Seq (Illumina) | inclusion |
| Sequencing viral strains for mutation | Typing of respiratory syncytial virus-A (RSV-A) and B (RSV-B) and sequencing of strains (Amplicons) | Inclusion |
| Comparison of respiratory syncytial virus (RSV) antibodies levels on newborn screening specimen and on capillary swab during infection | Levels of RSV antibodies will be measured and compared between newborn screening specimen and capillary swab during infection | Birth, Inclusion |
| Study the load of Streptococcus pneumoniae (Sp) in RSV infections. | Compare the serotypic profiles of pneumococcus (Sp) present during RSV infections | Inclusion |
| AP-HP,Raymond Poincaré Hospital | Recruiting | Garches | 92380 | France |
|
| Réanimation médico-chirurgicale Necker | Recruiting | Paris | 750 | France |
|
| D012140 |
| Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |