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The investigators hypothesize that Respiratory Syncytial Virus (RSV) infection may influence the population of lung immature myeloid cells and dendritic cells in a way that will impair their ability to invoke an effective immune response and lead to prolonged inflammation, angiogenesis and scarring. This may lead in turn to disturbed lung function.
Our aim is to determine the presence and phenotype of immature myeloid cells present in respiratory secretions of children with RSV bronchiolitis as compared to non-RSV bronchiolitis and healthy controls.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Children Suffering From Bronchiolitis | Respiratory secretions obtained from children suffering from Bronchiolitis |
| |
| Healthy Children | Respiratory secretions obtained from children with no respiratory infection |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Respiratory secretions obtained | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of Immature Myeloid Cells in Respiratory Secretions | Respiratory secretions obtained from child presenting with bronchiolitis will be examined for the presence of immature myeloid cells | Participants will be followed for the duration of hospital stay, an expected average of one week |
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Inclusion Criteria:
Exclusion Criteria:
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Children presenting in our pediatric department suffering from bronchiolitis
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hillel Yaffe Medical Center | Hadera | 38100 | Israel |
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| ID | Term |
|---|---|
| D001988 | Bronchiolitis |
| ID | Term |
|---|---|
| D001991 | Bronchitis |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D001982 | Bronchial Diseases |
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| D012140 |
| Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |