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Nature of potential dysbiosis, interrelation of the different microbiomes of the respiratory tract, and potential role of the immune system in the pathogenesis of severe asthma in infants, and its evolution under treatment.
Exploring and understanding these data is to improve patient care and discover new therapeutic targets.
The aim is to open up prospects for therapeutic studies, such as the use of azithromycin as an immunomodulator in infant asthma, the results of which are discordant.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| All patients | Other | All patients included will be followed for 1 year, every 3 months |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood sample | Other | An additionnal volume of blood will be collected at inclusion and at each follow-up visit |
|
| Measure | Description | Time Frame |
|---|---|---|
| description of microbiomes from bronchoalveolar fluids | analysis of bronchoalveolar fluids - NGS sequencing | Inclusion |
| description of microbiomes from nasopharyngeal samples | analysis of nasopharyngeal samples- NGS sequencing | Inclusion |
| description of microbiomes from sputum samples | analysis of sputum samples- NGS sequencing | Inclusion |
| description of microbiomes from bronchoalveolar fluids | analysis of bronchoalveolar fluids- NGS sequencing | at 3 months |
| description of microbiomes from nasopharyngeal samples | analysis of nasopharyngeal samples- NGS sequencing | at 3 months |
| description of microbiomes from sputum samples | analysis of sputum samples- NGS sequencing | at 3 months |
| description of microbiomes from bronchoalveolar fluids | analysis of bronchoalveolar fluids- NGS sequencing | at 6 months |
| description of microbiomes from nasopharyngeal samples | analysis of nasopharyngeal samples- NGS sequencing |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| David Mallet | Contact | 02 32 88 82 65 | +33 | secretariat.DRC@chu-rouen.fr |
| Name | Affiliation | Role |
|---|---|---|
| PETAT Hortense | University Hospital, Rouen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rouen University Hospital | Recruiting | Rouen | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40670979 | Derived | Petat H, Hassel C, Michel A, Charbonnier C, Plantier JC, Marguet C. Microbiosthma: a prospective study following respiratory microbiota in young children with severe preschool wheezing to better understand their respiratory future. BMC Pulm Med. 2025 Jul 16;25(1):342. doi: 10.1186/s12890-025-03812-9. |
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| ID | Term |
|---|---|
| D001249 | Asthma |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Expectoration | Other | Expectoration will be collected at inclusion and at each follow-up visit |
|
| Nasopharyngeal swab | Other | A nasopharyngeal swab will be collected at inclusion and at each follow-up visit after an induced sputum |
|
| at 6 months |
| description of microbiomes from sputum samples | analysis of sputum samples- NGS sequencing | at 6 months |
| description of microbiomes from bronchoalveolar fluids | analysis of bronchoalveolar fluids - NGS sequencing | at 9 months |
| description of microbiomes from nasopharyngeal samples | analysis of nasopharyngeal samples- NGS sequencing | at 9 months |
| description of microbiomes from sputum samples | analysis of sputum samples- NGS sequencing | at 9 months |
| description of microbiomes from bronchoalveolar fluids | analysis of bronchoalveolar fluids- NGS sequencing | at 12 months |
| description of microbiomes from nasopharyngeal samples | analysis of nasopharyngeal samples- NGS sequencing | at 12 months |
| Description of microbiomes from sputum samples | analysis of sputum samples- NGS sequencing | at 12 months |
| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |