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The aim of this study is to compare the efficacy double trigger [ co-administration of GnRH agonist with HCG 40 and 34 h prior to ovum pick-up, respectively] with HCG trigger in inducing oocyte maturation.
Several studies revealed that the double trigger regimen was effective in the treatment of patients with a history of immature oocytes retrieved or with suboptimal oocytes yield.
The investigators designed this randomized controlled trial to compare the efficacy double trigger with HCG trigger in inducing oocyte maturation.in normoreponders undergoing IVF-ET
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Double trigger | Experimental | GnRH agonist ( Triptorelin ) ( 0.2 mg / S.C ) and hCG ( 10000 IU) are administered 40 and 34 h before oocyte retrieval |
|
| HCG trigger | Active Comparator | HCG ( 100000 IU/ I.M ) is administered 36 h before oocyte retrieval |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Double trigger | Drug | GnRH agonist ( Triptorelin ) ( 0.2 mg / S.C ) and hCG ( 10000 IU) are administered 40 and 34 h before ovum pick-up |
|
| Measure | Description | Time Frame |
|---|---|---|
| Metaphase-II oocytes rate | Number of MII oocyte/ number of cumulus oocyte complex | Ten to fifteen days after starting ovarian stimulation |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical pregnancy rate | Presence of intrauterine gestational sac detected by transvaginal ultrasound | 5 weeks after embryo transfer |
| Ongoing Pregnancy Rate | Pregnancies continued beyond 20 weeks gestation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Usama M Fouda, Prof. | Contact | +201095401375 | umfrfouda@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Ismail Aboul Foutouh, Prof. | Cairo University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bedaya Hospital | Giza | Egypt |
|
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25296696 | Background | Haas J, Zilberberg E, Dar S, Kedem A, Machtinger R, Orvieto R. Co-administration of GnRH-agonist and hCG for final oocyte maturation (double trigger) in patients with low number of oocytes retrieved per number of preovulatory follicles--a preliminary report. J Ovarian Res. 2014 Aug 2;7:77. doi: 10.1186/1757-2215-7-77. |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| HCG trigger | Drug | hCG ( 10000 IU) is administered 36 h before ovum pick-up |
|
|
| 18 weeks after embryo transfer |