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The aim of this randomized controlled trial is to determine whether co-administration of GnRH agonist and hCG for final oocyte maturation ( 40 and 34 h prior to oocyte retrieval , respectively) can increase the number of mature oocytes in patients with history of low proportion of mature oocytes in previous IVF cycle triggered by HCG.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Double trigger | Experimental | GnRH-agonist and HCG are used to trigger ovulation |
|
| HCG | Active Comparator | HCG is used to trigger ovulation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Double trigger | Drug | Final follicular maturation is triggered by the coadministration of GnRH-agonist (Triptorelin acetate, decapeptyl 0.2 mg, Slough, United Kingdom) and 10000 IU of HCG, 40 and 34 h prior to oocyte retrieval, respectively |
| Measure | Description | Time Frame |
|---|---|---|
| Number of oocytes retrieved | First day after oocyte retrieval |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical pregnancy rate | The presence of gestational sac detected by ultrasound examination | First 5 weeks after oocyte retrieval |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Usama M Fouda, Prof. | Contact | +201095401375 | umfrfouda@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Usama M Fouda, Prof. | Riyadh Fertility and Reproductive Health center | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Riyadh Fertility and Reproductive Health center | Recruiting | Giza | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25385007 | Background | Zilberberg E, Haas J, Dar S, Kedem A, Machtinger R, Orvieto R. Co-administration of GnRH-agonist and hCG, for final oocyte maturation (double trigger), in patients with low proportion of mature oocytes. Gynecol Endocrinol. 2015 Feb;31(2):145-7. doi: 10.3109/09513590.2014.978850. Epub 2014 Nov 11. |
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| ID | Term |
|---|---|
| D007247 | Infertility, Female |
| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| HCG trigger | Drug | Final follicular maturation is triggered by a dose of 10000 IU of HCG 36 h prior to oocyte retrieval |
|
| D000091662 | Genital Diseases |
| D007246 | Infertility |