Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The aim of this randomized controlled study is to compare the efficacy of a modified dual trigger protocol [a single bolos of HCG combined with two successive doses of a GnRH agonist ] with HCG [a single bolos administered 36 hours before oocyte retrieval ] in triggering ovulation in normo-responders undergoing ovarian stimulation using the antagonist protocol.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Modified dual trigger group | Experimental | HCG is administered 36 hours before ovum pickup and two successive doses of GnRH are administered 36 and 24 hours before ovum pickup. |
|
| HCG group | Active Comparator | A single dose of HCG is administered 36 hours before oocyte retrieval |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Modified dual trigger | Drug | HCG (10000 IU /IM) and triptorelin (0.2 mg/S.C) are administered 36 hours before ovum pickup . Moreover, 0.1mg of triptorelin is administered 24 h prior to ovum pick-up. |
| Measure | Description | Time Frame |
|---|---|---|
| Metaphase-II oocytes rate | Number of MII oocyte/ number of cumulus oocyte complex | Ten to fifteen days after starting ovarian stimulation |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical pregnancy rate | Presence of intrauterine gestational sac detected by transvaginal ultrasound | Five weeks after embryo transfer |
| Ongoing pregnancy Rate | Pregnancies continued beyond 20 weeks gestation |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Usama M Fouda, Prof | Contact | +201095401375 | umfrfouda@yahoo.com |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bedaya Hospital | Giza | Giza Governorate | 3753303 | Egypt |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| HCG | Drug | HCG (10000 IU/IM ) is administered 36 hours before ovum pickup. |
|
| Eighteen weeks after embryo transfer |