Noninvasive Positive Pressure Ventilation During Neonatal Nasal Intubation

The IntubAID Study - Noninvasive Positive Pressure Ventilation During Neonatal Nasal Intubation

The goal of this study is to perform a quality control assessment of our local intubation protocol in any newborn infant requiring endotracheal intubation in the delivery room or neonatal intensive care unit at the Department of Neonatology of the University Hospital Zurich. The primary aims are:

• Successful nasal intubation at the first attempt without physiological instability.
• Comparison of infants with successful intubation at the first attempt without physiological instability to the infants in the SHINE-Trial in Australia.

Participants will be intubated according to our standard intubation procedure using non-invasive ventilation (NIV) delivered through a nasopharyngeal tube.

Inclusion Criteria:

• Any neonate at the Department of Neonatology of the University Hospital Zurich undergoing endotracheal intubation in the delivery room or neonatal intensive care unit.

Exclusion Criteria:

• Requirement for immediate endotracheal intubation as determined by the treating clinician, without time for potential application of NIPPV, e.g. active cardiopulmonary resuscitation.
• Contraindication to NIPPV use (e.g. congenital diaphragmatic hernia, abdominal wall defects).
• Oral intubation planned.
• Denial of parental consent and/or inability of the parents to understand the study procedures due to cognitive or linguistic reasons.
• Withdrawal at the discretion of the intubating clinician if he / she feels the study is interfering with a safe and optimal treatment of the patient.