Evaluation of Genetic Signature in Endometriosis Disease by Non Invasive Sampling

Evaluation of Genetic Signature in Endometriosis Disease by Non Invasive Sampling

Endometriosis is a disease that affects 10-15% of the general population and 50% of infertile women. It is characterized by the presence of endometrial tissue outside the uterine cavity. Endometriosis can lead to infertility by interfering through endocrine and mechanical alterations on the function of the ovaries, fallopian tubes, and uterus. The aim of the study is to define the differential expression of a cluster of RNAs tissue driven for the identification of an RNA profile in saliva, specific for endometriosis. This study focuses on the expression of genes involved in the control and regulation of apoptosis, cell survival, metabolism, cell adhesion and invasion, angiogenesis, inflammation, and estrogen receptor expression levels.

Retrospective selection based on anamnestic criteria of: 50 patients with diagnosed endometriotic adnexal pathology (case, CA), 50 patients with non-endometriotic adnexal pathology (control, CO) and 50 patients with no gynecological pathology, not undergoing surgery (analytical control).

The study involves collecting a saliva sample from all patients involved in the study, and performing a biopsy from both patients with endometriotic adnexal pathology (CA) and patients with non-endometriotic adnexal pathology (CO).

Inclusion Criteria:

• Case population (CA), patients with endometriotic adnexal pathology
• Control population (CO), patients with non-endometriotic adnexal pathology
• Analytical control population (C-), patients with no gynecologic pathology, not undergoing surgery

Exclusion Criteria:

• Women with ages outside the inclusion range
• Pregnant patient
• Patient with a personal history of cancer
• Patient infected with HIV