Biomarkers in the Endometrial Fluid, Tissue, and Follicular Fluid of Moderate/Severe Endometriosis Patients

An Exploratory Study of Biomarkers in the Endometrial Fluid, Tissue, and Follicular Fluid of Moderate/Severe Endometriosis Patients: a Prospective Study

This study aims to explore biomarkers in the endometrial fluid and tissue of women with moderate to severe endometriosis, with a specific focus on those involved in pre-receptive endometrium and embryo implantation. This research has the potential to uncover diagnostic indicators of impaired pre-receptive endometrium, examine pathophysiological pathways, and identify future targets for therapeutic intervention. Ultimately, the findings may contribute to more personalized fertility treatments, offering new hope for women struggling with endometriosis-related infertility.

Inclusion Criteria:

• Age 18-40 years old
• Diagnosed with moderate/severe endometriosis by ultrasound or laparoscopy (patient group)
• Regular menstrual cycles 28-35 days
• Speak English or Swedish and agree to participate in the study

Exclusion Criteria:

• Pregnancy or lactation in the last 3 months
• Uterine anomalies
• Pelvic inflammatory disease, endometritis, STD
• Gynaecological cancers or other malignancies in the patient's history
• Smoking (more than 10 cigarettes per day) or alcohol abuse
• Immunosuppressing medicines
• Major abdominal or pelvic surgery in the last 3 months
• A specific genetic disease that is diagnosed before PGT in women undergoing treatment