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Low flow anesthesia; It is an anesthesia practice in which, after absorbing at least 50% of the exhaled air and carbon dioxide (CO2) using a semi-closed rebreathing system, the unused anesthetic gases are mixed with a certain amount of fresh gas and then completely or partially returned to the patient in the next inspiration. Theoretically, when low flow anesthesia is compared to high or normal flow anesthesia; it is known to have advantages such as using less inhalation agent, preserving mucociliary activity, preventing microatelectasis, preserving the amount of moisture, and reducing temperature loss.
In studies conducted in different fresh gas flows, it has been observed that CO, which is thought to accumulate in the body by rebreathing in a closed circuit, increases as a result of the chemical interaction and dry CO2 absorbent. However, there is no evidence in these studies that low-flow anesthesia increases CO accumulation and alters hemodynamics.
In our clinic, low-flow and high-flow anesthesia technics are both being used. In this study, we aimed to evaluate the effects of high- and low-flow sevoflurane anesthesia applied with a closed system on perioperative carboxyhemoglobin (COHb) levels and hemodynamic system in pediatric cardiovascular surgery cases.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low-flow anesthesia group | In this group, ventilation parameters is adjusted to have fresh gas flow/minute ventilation ratio below 0.5 |
| |
| High-flow anesthesia group | In this group, ventilation parameters is adjusted to have fresh gas flow/minute ventilation ratio above 1.0 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| low and high flow | Other | low and high flow anesthesia are both being used. The effects of different gas flows will be evaluated. |
|
| Measure | Description | Time Frame |
|---|---|---|
| COHb levels | COHb values will be measured in arterial blood gas samples at different fresh gas flow levels. | at the 30th minute of the surgery, at the beginning of cardiopulmonary bypass, at the time of chest closure, at the time of intensive care unit admission |
| Measure | Description | Time Frame |
|---|---|---|
| extubation time | the time of extubation | at the time that patient is extubated up to 24 hours |
| body temperature | body temperature | at the 30th minute of the surgery, at the beginning of cardiopulmonary bypass, at the time of chest closure, at the time of intensive care unit admission |
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Inclusion Criteria:
Exclusion Criteria:
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Patients will be selected among the patients who will undergo cardiac surgery at Basaksehir Cam and Sakura City Hospital Pediatric Cardiovascular Surgery Clinic.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hazal Ozsagiroglu | Contact | +905387284700 | hazalozsagiroglu@gmail.com | |
| Selin Saglam | Contact | +905557198756 | selinsaglams@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Basaksehir Cam and Sakura City Hospital | Recruiting | Istanbul | Turkey (Türkiye) |
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| bleeding | Total amount of bleeding during the first 24 hours | 24 hours |
| vasoactive inotrope score (VIS) | VIS at the end of the operation | postoperative first hour |