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| ID | Type | Description | Link |
|---|---|---|---|
| Recep Tayyip ErdoganUniversity | Other Identifier | Recep Tayyip Erdogan University |
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Periodontitis is an inflammatory disease that causes destruction of periodontal tissues. IL-20, on the other hand, is known as a potent angiogenic, chemotactic, and pro-inflammatory cytokine associated with various chronic inflammatory disorders. IL-20 has a significant role in the regulation of osteoclastogenesis and osteoblastogenesis. The aim of this study was to evaluate the effect of IL-20 on periodontal destruction.
In the study, a total of 60 participants were included, 30 of whom were systemically and periodontally healthy (control group) and 30 of whom were systemically healthy and had periodontitis (periodontitis group). GCF and serum samples were collected from the participants for biochemical analysis. ELISA method was used to determine IL-20, TNF-α, IL1β/IL-10, RANKL/OPG and MMP8 levels
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control group (periodontally healthy) | no attachment loss, probing pocket depth ≤ 3 mm, minimal bleeding on probing ≤ 10%, and no radiographic bone loss |
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| periodontitis group | interdental clinical attachment level ≥ 5 mm, probing pocket depth ≥ 6 mm, radiographic bone loss extending to the middle or apical thirds of the root, mid-crest defect, and a history of ≤4 teeth loss of periodontal origin |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| biochemical analysis | Other | GCF and serum samples were collected from the participants for biochemical analysis. |
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| Measure | Description | Time Frame |
|---|---|---|
| concentration of biochemical findings in gingival crevicular fluid (GCF) | IL-20, RANKL, OPG and RANKL/OPG values eveluated in GCF | june 2022-june 2023 |
| concentration of biochemical findings in serum | IL-20, RANKL, OPG, RANKL/OPG, MMP-8, TNF-α, IL-1β, IL-10 and IL-1β/IL-10 | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| value of periodontal clinical parameters | plaque index (PI) (Silness & Löe), gingival index (GI) (Silness & Löe) and bleeding on probing index (BOP) of all natural teeth of the patients | 1 year |
| value of periodontal clinical parameters were measured in mm |
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Inclusion Criteria:
Exclusion Criteria:
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This study included individuals who applied to Recep Tayyip Erdogan University, Faculty of Dentistry, Department of Periodontology for treatment
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| Name | Affiliation | Role |
|---|---|---|
| Yemenoglu | Recep Tayyip Erdogan University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Recep Tayyip Erdogan University | Rize | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D010518 | Periodontitis |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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serum and gingival crevicular fluid
probing pocket depth (PPD), clinical attachment loss (CAL) of all natural teeth of the patients |
| 1 year |