Neostigmine Versus Sugammadex on Renal Functions

Evaluation of The Effects of Neostigmine Versus Sugammadex on Renal Functions in Laparoscopic Cholecystecomy A Randomized Controlled Study

The study will assess the acute effects of sugammadex or neostigmine on renal function as determined with more specific and sensitive tests in laparoscopic cholecystectomy

Inclusion Criteria:

• normal renal function (serum Cr 0.4- 1.4 g/dL)
• American Society of Anesthesiologists (ASA) Class I-II

Exclusion Criteria:

• Incapacity to consent.
• Pre-existing impaired kidney functions.
• Severe neuromuscular disease, as: myasthenia gravis & muscular dystrophy.
• Intra-operative bleeding
• Lengthy operations that exceed 2 hours.
• Hemodynamic changes more than 20% of the base line