Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Guizhou Center for Disease Control and Prevention | OTHER |
Not provided
Not provided
Not provided
Not provided
The goal of this observational study is to investigate the proportion of Mycobacterium tuberculosis (MTB) infection in school contacts of active tuberculosis (ATB) patients. The main questions it aims to answer are:
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Contacts | School contacts of ATB patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| QuantiFERON-TB Gold (QFT) test | Diagnostic Test | Participants will be tested by QuantiFERON-TB Gold (QFT) test to see if they have ever infected by MTB. Those with positive results will proceed to sputum Xpert MTB/RIF, physical examination and chest CT scan, as well as sputum culture if necessary to distinguish latent TB infection (LTBI) from ATB. X-ray scan is conditional on age above 15 years with a positive QuantiFERON-TB Gold (QFT) test result. |
| Measure | Description | Time Frame |
|---|---|---|
| The prevalence of tuberculosis (TB) infection in school contacts | The prevalence of TB infection is defined as the number of participants with positive results in QuantiFERON-TB Gold (QFT) test in study population. Positive result in QFT test indicates higher response than the cut-off value of 0.35 IU / ml of INF-γ detected in at least one test tube (TB1 or TB2). | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Age | Age as possible risk factor of tuberculosis infection | baseline |
| Sex | Sex as possible risk factor of tuberculosis infection. | baseline |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Students in junior middle schools, high schools and universities from Guizhou Province, China
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Qiaoling Ruan, PhD | Contact | 13661856002 | ruan_qiao_ling@fudan.edu.cn | |
| Jinlan Li, MPH | Contact | 13985045080 | 740820442@qq.com |
| Name | Affiliation | Role |
|---|---|---|
| Wenhong Zhang, PhD | Huashan Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xinpu New Area Center of Disease Control | Recruiting | Zunyi | Guiyang | China |
This research targets adolescent students in school. We decide not to share IPD from the ethical perspective.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
peripheral blood
|
|
| Vaccination history checklist | Bacillus Calmette-Guérin (BCG) vaccination history as possible risk factor of tuberculosis infection. | baseline |
| Patterns of contacting checklist | Duration, size of space of exposure to active tuberculosis-infected patient; as possible risk factor of tuberculosis infection. | baseline |
| Co-morbidities / medical history checklist | Co-morbidities / medical history [cardiovascular disease, bronchial asthma, digestive ulcer, nephritic syndrome, glomerulonephritis, diabetes, hyperthyroidism, systemic lupus erythematosus, ankylosing spondylitis, epilepsy, schizophrenia, depression, HIV infection, glucocorticoid use, biologic agent use, immunosuppressive agent use, or other relevant co-morbidities / medical history]; as possible risk factor of tuberculosis infection. | baseline |
| Dafang Center for Disease Control and Prevention | Recruiting | Bijie | Guizhou | 551600 | China |
|
| Qixingguan Center for Disease Control and Prevention | Recruiting | Bijie | Guizhou | 551700 | China |
|
| Nayong Center for Disease Control and Prevention | Recruiting | Bijie | Guizhou | 553307 | China |
|
| Hezhang Center for Disease Control | Recruiting | Bijie | Guizhou | China |
|
| Jinsha Center for Disease Control | Recruiting | Bijie | Guizhou | China |
|
| Qianxi Center of Disease Control | Recruiting | Bijie | Guizhou | China |
|
| Weining Center of Disease Control | Recruiting | Bijie | Guizhou | China |
|
| Zhijin Center of Disease Control | Recruiting | Bijie | Guizhou | China |
|
| Liping Center for Disease Control and Prevention | Recruiting | Linping | Guizhou | 557300 | China |
|
| Liuzhi Special District Center of Disease Control | Recruiting | Liupanshui | Guizhou | China |
|
| Panzhou Center of Disease Control | Recruiting | Liupanshui | Guizhou | China |
|
| Shuicheng District Center of Disease Control | Recruiting | Liupanshui | Guizhou | China |
|
| Cengong Center of Disease Control | Recruiting | Qiandongnan Miao and Dong Autonomous Prefecture | Guizhou | China |
|
| Congjiang Ceter of Disease Control | Recruiting | Qiandongnan Miao and Dong Autonomous Prefecture | Guizhou | China |
|
| Danzhai Center of Disease Control | Recruiting | Qiandongnan Miao and Dong Autonomous Prefecture | Guizhou | China |
|
| Huangping Center of Disease Control | Recruiting | Qiandongnan Miao and Dong Autonomous Prefecture | Guizhou | China |
|
| Jianhe Center of Disease Control | Recruiting | Qiandongnan Miao and Dong Autonomous Prefecture | Guizhou | China |
|
| Jinping Center of Disease Control | Recruiting | Qiandongnan Miao and Dong Autonomous Prefecture | Guizhou | China |
|
| Kaili Center of Disease Control | Recruiting | Qiandongnan Miao and Dong Autonomous Prefecture | Guizhou | China |
|
| Leishan Center of Disease Control | Recruiting | Qiandongnan Miao and Dong Autonomous Prefecture | Guizhou | China |
|
| Majiang Center of Disease Control | Recruiting | Qiandongnan Miao and Dong Autonomous Prefecture | Guizhou | China |
|
| Rongjiang Center of Disease Control | Recruiting | Qiandongnan Miao and Dong Autonomous Prefecture | Guizhou | China |
|
| Sansui Center of Disease Control | Recruiting | Qiandongnan Miao and Dong Autonomous Prefecture | Guizhou | China |
|
| Shibing Center of Disease Control | Recruiting | Qiandongnan Miao and Dong Autonomous Prefecture | Guizhou | China |
|
| Taijiang Center of Disease Control | Recruiting | Qiandongnan Miao and Dong Autonomous Prefecture | Guizhou | China |
|
| Tianzhu Center of Disease Control | Recruiting | Qiandongnan Miao and Dong Autonomous Prefecture | Guizhou | China |
|
| Zhenyuan Center of Disease Control | Recruiting | Qiandongnan Miao and Dong Autonomous Prefecture | Guizhou | China |
|
| Qingzhen Center for Disease Control and Prevention | Recruiting | Qingzhen | Guizhou | 551400 | China |
|
| Bozhou District Center of Disease Control | Recruiting | Zunyi | Guizhou | China |
|
| Chishui Center of Disease Control | Recruiting | Zunyi | Guizhou | China |
|
| Daozhen Center of Disease Control | Recruiting | Zunyi | Guizhou | China |
|
| Fenggang Center of Disease Control | Recruiting | Zunyi | Guizhou | China |
|
| Honghuagang District Center of Disease Control | Recruiting | Zunyi | Guizhou | China |
|
| Huichuan District Center of Disease Control | Recruiting | Zunyi | Guizhou | China |
|
| Meitan Center of Disease Control | Recruiting | Zunyi | Guizhou | China |
|
| Renhuai Center of Disease Control | Recruiting | Zunyi | Guizhou | China |
|
| Suiyang Center of Disease Control | Recruiting | Zunyi | Guizhou | China |
|
| Tongzi Center of Disease Control | Recruiting | Zunyi | Guizhou | China |
|
| Wuchuan Center of Disease Control | Recruiting | Zunyi | Guizhou | China |
|
| Xishui Center of Disease Control | Recruiting | Zunyi | Guizhou | China |
|
| Yuqing Center of Disease Control | Recruiting | Zunyi | Guizhou | China |
|
| Zhengan Center of Disease Control | Recruiting | Zunyi | Guizhou | China |
|
| Dalian Public Health Clinical Center | Recruiting | Dalian | Liaoning | China |
|
| ID | Term |
|---|---|
| D014376 | Tuberculosis |
| D055985 | Latent Tuberculosis |
| ID | Term |
|---|---|
| D009164 | Mycobacterium Infections |
| D000193 | Actinomycetales Infections |
| D016908 | Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
| D000085343 | Latent Infection |
Not provided
Not provided