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| Name | Class |
|---|---|
| Charles University, Czech Republic | OTHER |
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TB-reactive immune cells will be tested in a multiparametric flow cytometry to distinguish an immune response for antigens of Mycobacterium spp. in TB disease/latent infection or a reaction after BCG vaccine.
The goal of this project is the verification of current cytometric panel of detection antibodies in a wider panel of stimulative immunodominant antigens for CD4+ and CD8+ T cells in combination with adjuvants 2 in a in vitro activating test.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Contact with active TB/ LTBI | After a close contact with bacteriologically confirmed TB suspicion for LTBI with an evidence of previous BCG vaccination status TB confirmed with TST (TST ≥ 5 mm or BCG unvaccinated or TST ≥ 15 mm for BCG vaccinated) 20 children and adolescents 20 adults |
| |
| Active TB group | Active TB group with positive microbial culture and pathological chest radiography or chest CT 20 children and adolescents 20 adults |
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| Contact with active TB/ negative | After a close contact with bacteriologically confirmed TB no evidence of TB in TST or IGRA test for 3 months 20 children and adolescents 20 adults |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood draw | Diagnostic Test | Blood draw and the analysis of blood in laboratory |
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| Measure | Description | Time Frame |
|---|---|---|
| Peer-review publication of results of our study | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Creation of new diagnostic tool and his comparision with existing IGRA test (QTF-GP and TST) | 2 years |
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Inclusion Criteria: active TB, contact with TB infection in previous 3 months before the study
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Exclusion Criteria:
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Study of the broad spectrum of population with the history of having an active TB infection or close contact with bacteriologically approved pulmonary TB
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Petra Hadlová, MGR | Contact | +724077200 | Petra.hadlova@natur.cuni.cz | |
| Karolína Doležalová, MD | Contact | +420777246841 | karolina.dolezalova@ftn.cz |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Science | Recruiting | Prague | 12800 | Czechia |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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30 ml of blood
| Thomayer Hospital | Recruiting | Prague | 14059 | Czechia |
|
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |