The Effect of Intermittent Fasting on Brain Health

Time Restricted Eating for Prevention of Age-related Vascular Cognitive Decline in Older Adults

The central hypothesis of this study is that closer adherence to time restricted eating (TRE) will improve endothelial function, neurovascular (NVC) responses, resulting in improved cognitive performance, potentially through activation of SIRT1-dependent vasoprotective pathways.

This hypothesis will be tested by assessing the effect of TRE (not more than 10hr eating window each day for 6 months) in healthy older adults (55-80 years of age).

Inclusion Criteria:

• Age ≥55 and ≤80 years of age
• Adequate hearing and visual acuity to participate in the examinations
• Ability to read and write in English
• Competence to provide informed consent.
• Mini Montreal Cognitive Assessment ≥12
• Mini Nutritional Assessment ≥12

Exclusion Criteria:

• Vision or hearing impairment that would impair the ability to complete study assessments
• Active CNS disease including multiple sclerosis, uncontrolled seizures, active brain cancer
• Cerebrovascular accident other than TIA within 60 days prior to Visit 0
• Major psychiatric disease, including major depression not currently controlled on medications, alcohol or drug abuse
• Diabetics prescribed sulfonylureas, meglitinides, and insulin
• Any other medical condition which, in the opinion of investigator, would render the patient inappropriate or too unstable to complete the study protocol