Cerebromicrovascular Effects of Time-Restricted Eating in Older Adults

Cerebromicrovascular Effects of Time-Restricted Eating in Older Adults

The central hypothesis of this study is that closer adherence to time restricted eating (TRE) will improve endothelial function, neurovascular (NVC) responses, resulting in improved cognitive performance, potentially through activation of SIRT1-dependent vasoprotective pathways.

This hypothesis will be tested by assessing the effect of TRE (not more than 10hr eating window each day for 6 months) in healthy adults (≥21 years of age).

Inclusion Criteria:

• Age ≥21 years
• Adequate hearing and visual acuity to participate in examinations
• Ability to read and write in English
• Competence to provide informed consent

Exclusion Criteria:

• Vision or hearing impairment that would impair the ability to complete study assessments
• Active CNS disease including multiple sclerosis, uncontrolled seizures, and active brain cancer
• Cerebrovascular accident other than TIA within 60 days prior to screening
• Any other medical condition which, in the opinion of the investigator, would render the participant inappropriate or too unstable to complete the study protocol