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| Name | Class |
|---|---|
| University Medical Centre Ljubljana | OTHER |
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The results of contemporary studies suggest an association between inflammatory periodontal disease and pregnancy and delivery complications. The aim of this study was to assess the association between periodontal disease, clinical periodontal parameters and pregnancy or delivery complications in type 1 diabetes mellitus and non-diabetic pregnant women.
The results of contemporary studies suggest an association between inflammatory periodontal disease and pregnancy and delivery complications. The aim of this study was to assess the association between periodontal disease, clinical periodontal parameters and pregnancy or delivery complications in type 1 diabetes mellitus and non-diabetic pregnant women. Methods: 15 type 1 diabetes mellitus and 15 non-diabetic primiparous women were enrolled in the prospective "case-control" study. Investigators compared periodontal status, levels of glycosylated haemoglobin (HbA1c), high sensitivity C-Reactive Protein (hs-CRP), gestational week of birth, birth weight of a newborn and pregnancy or delivery complications (C-section, pre-eclampsia) between the groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Group | Healthy pregnant women |
| |
| Case Group | Pregnant women with Diabetes Mellitus Type 1 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pregnancy and/or delivery complications | Other | Analysis of post-delivery reports for pregnancy and/or delivery complications. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of Delivery and/or Pregnancy complications | Yes/No | Day of delivery |
| Number of C-section | Yes/No | Day of delivery |
| Number of pregnant women with Pre-eclampsia | Yes/No | Between 28th and 34th week of gestation |
| Number of Pre-term births GWOB (Gestational week of birth) ≤ 37th week | Yes/No | Day of delivery |
| GWOB - Gestational week of birth | Week number | Day of delivery |
| number of Births with weight ≤ 2500 g | Yes/No | Day of delivery |
| Birth weight | Weight in kg | Day of delivery |
| Number of pregnant women with Periodontal disease | Yes/No | Between 28th and 34th week of gestation |
| Measure | Description | Time Frame |
|---|---|---|
| Age | Age | Between 28th and 34th week of gestation |
| BMI (Body mass index) | Body mass index - measure of body fat based on height and weight (BMI = Weight (kg) / Height (m)²) |
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Inclusion Criteria:
Exclusion Criteria:
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Pregnant women included in study entitled: Periodontal status of type 1 diabetes mellitus and healthy pregnant women: a case-control study from Slovenia
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| Name | Affiliation | Role |
|---|---|---|
| Rok Schara, DMD, PhD | Assistant Professor | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17116160 | Background | Bassani DG, Olinto MT, Kreiger N. Periodontal disease and perinatal outcomes: a case-control study. J Clin Periodontol. 2007 Jan;34(1):31-9. doi: 10.1111/j.1600-051X.2006.01012.x. Epub 2006 Nov 20. | |
| 16889630 | Background | Bosnjak A, Relja T, Vucicevic-Boras V, Plasaj H, Plancak D. Pre-term delivery and periodontal disease: a case-control study from Croatia. J Clin Periodontol. 2006 Oct;33(10):710-6. doi: 10.1111/j.1600-051X.2006.00977.x. Epub 2006 Aug 3. |
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All Research data will be available or shared on individual request. Example: conducting Meta-Analysis.
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| Periodontal disease | Other | Measuring clinical periodontal parameters for assessing presence of periodontal disease. |
|
| Between 28th and 34th week of gestation |
| PPD (Probing pocket depth) | Probing pocket depth (measured on 6 sites around teeth, unit: mm) | Between 28th and 34th week of gestation |
| CAL (Clinical attachment loss) | Clinical attachment loss (measured on 6 sites around teeth, unit: mm) - This is the measurement of the position of the soft tissue attachment in relation to the cemento-enamel junction (CEJ). Two measurements are used to calculate the CAL: the probing depth and the distance from the gingival margin to the CEJ. | Between 28th and 34th week of gestation |
| percantage of sites with BOP (Bleeding on probing) | Bleeding on probing, Yes/No after probing pocket depth measurement 6 sites around each tooth. Unit: % | Between 28th and 34th week of gestation |
| TPIB (Total periodontal inflammatory burden) | Total periodontal inflammatory burden - measures of average teeth neck circumferences by tooth type, probing depth (PD) and bleeding on probing (BOP). The subgingival area for each tooth was calculated by multiplying 1/6th of the average cervical circumference of the tooth with each of the six measurements of probing depth. The sum of subgingival areas of all present teeth in a subject represented the total subgingival area of an individual. | Between 28th and 34th week of gestation |
| TBPW area (Total bleeding periodontal wound) | Total bleeding periodontal wound - measures of average teeth neck circumferences by tooth type, probing depth (PD) and bleeding on probing (BOP). The subgingival area for each tooth was calculated by multiplying 1/6th of the average cervical circumference of the tooth with each of the six measurements of probing depth. The sum of subgingival bleeding areas of all present teeth in a subject represented the total subgingival area of an individual. | Between 28th and 34th week of gestation |
| Percantage of HbA1C (Glycosylated haemoglobin) | Glycosylated haemoglobin, Unit: % | Between 28th and 34th week of gestation |
| 18496486 | Background | Sacco G, Carmagnola D, Abati S, Luglio PF, Ottolenghi L, Villa A, Maida C, Campus G. Periodontal disease and preterm birth relationship: a review of the literature. Minerva Stomatol. 2008 May;57(5):233-46, 246-50. English, Italian. |
| 12666980 | Background | Champagne CM, Madianos PN, Lieff S, Murtha AP, Beck JD, Offenbacher S. Periodontal medicine: emerging concepts in pregnancy outcomes. J Int Acad Periodontol. 2000 Jan;2(1):9-13. |
| 23631578 | Background | Ide M, Papapanou PN. Epidemiology of association between maternal periodontal disease and adverse pregnancy outcomes--systematic review. J Periodontol. 2013 Apr;84(4 Suppl):S181-94. doi: 10.1902/jop.2013.134009. |
| 18295179 | Background | Ruma M, Boggess K, Moss K, Jared H, Murtha A, Beck J, Offenbacher S. Maternal periodontal disease, systemic inflammation, and risk for preeclampsia. Am J Obstet Gynecol. 2008 Apr;198(4):389.e1-5. doi: 10.1016/j.ajog.2007.12.002. Epub 2008 Mar 4. |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D010518 | Periodontitis |
| D011248 | Pregnancy Complications |
| D011254 | Pregnancy in Diabetics |
| D003922 | Diabetes Mellitus, Type 1 |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
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