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This study evaluated the periodontal condition of gestational diabetes mellitus (GDM) patients and a healthy non-pregnant control group. For the GDM group all medical data were recorded, including obesity/insulin resistance indicators.
Gestational diabetes mellitus is associated to a worse periodontal condition. Many patients with these two diseases are also obese. After delivery, some patients maintain the pre-pregnancy obesity status and this condition is also associated to periodontal disease. The mechanisms involved in the relationship of all these medical and periodontal conditions are not clear.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GDM group | Gestational diabetes mellitus patients under treatment of an endocrinologist |
| |
| Control | Healthy non-pregnant females |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Gestational diabetes mellitus | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Periodontal disease (gingivitis and periodontitis) measured by a periodontal probe and classified according to severity | Severe periodontitis was defined by the presence of ≥ 2 interproximal sites in different teeth with CAL ≥ 6mm and ≥1 interproximal site with PPD ≥5mm. Moderate periodontitis was defined by the presence of ≥ 2 interproximal sites in different teeth with CAL ≥ 4mm or ≥ 2 interproximal sites in different teeth with PPD ≥5mm. Mild periodontitis was defined as ≥ 2 interproximal sites in different teeth with ≥ 3 mm CAL and ≥ 2 interproximal sites in different teeth with ≥ 4 mm PPD or at least 1 site with PPD ≥ 5 mm (20,21). Gingivitis was determined as follows: Subjects were considered healthy if presented PPD ≤3mm/BOP extent scores < 10% and with gingivitis if presented PPD ≤3mm/ BOP extent scores >10%. Prevalence of periodontal disease was the sum of gingivitis, mild, moderate and severe periodontitis. | One day |
| Obesity measured by a tape and a scale | Obese if: body mass index - BMI ≥ 25 Kg/m2 (weight in kilograms, height in meters) Obese if : waist-to-hip ratio - WHR >0.85 (cm) | one day |
| Gestational diabetes mellitus diagnosed by an endocrinologist | Diagnosis stablished by a doctor based on glucose determination. The data was registered in the patient's medical chart. | one day |
| Measure | Description | Time Frame |
|---|---|---|
| Dyslipidemia as an indicator of obesity/insulin resistance | The data was registered in the patient's medical chart. Dyslipidemia = HDL ≤ 35 mg/dL / LDL≥ 100 mg/dL / Total cholesterol ≥200 mg/dL / Triglycerides ≥ 150 mg/dL / VLDL < 30 mg/dL | one day |
| Leukocytosis as an indicator of inflammation |
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Inclusion Criteria:
Exclusion Criteria:
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Only female participants
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| Name | Affiliation | Role |
|---|---|---|
| Carla Damante, PhD | University of Sao Paulo | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bauru School of Dentistry | Bauru | São Paulo | 17012-901 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24354652 | Background | Xie Y, Xiong X, Elkind-Hirsch KE, Pridjian G, Maney P, Delarosa RL, Buekens P. Prepregnancy obesity and periodontitis among pregnant females with and without gestational diabetes mellitus. J Periodontol. 2014 Jul;85(7):890-8. doi: 10.1902/jop.2013.130502. Epub 2013 Dec 19. |
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| ID | Term |
|---|---|
| D016640 | Diabetes, Gestational |
| D010510 | Periodontal Diseases |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D003920 | Diabetes Mellitus |
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The data was registered in the patient's medical chart. ≥ 10.000/L |
| one day |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |