The Fourth Left Atrial Appendage Occlusion Study (LAAOS-4)
The Fourth Left Atrial Appendage Occlusion Study (LAAOS-4)
LAAOS-4 aims to determine if catheter-based endovascular left atrial appendage occlusion prevents ischemic stroke or systemic embolism in participants with atrial fibrillation, who remain at high risk of stroke, despite receiving ongoing treatment with oral anticoagulation.
LAAOS-4 is a multicentre, prospective, open-label, randomized controlled trial with blinded assessment of endpoints (PROBE) to determine if catheter-based endovascular left atrial appendage occlusion prevents ischemic stroke or systemic embolism in participants with atrial fibrillation, who remain at high risk of stroke, despite receiving ongoing treatment with oral anticoagulation.
Inclusion Criteria:
Exclusion Criteria:
LAAOS-4@phri.ca905-521-2100
Jonesboro, Arkansas 72401, United States
Sacramento, California 95816, United States
Atlantis, Florida 33462, United States
Largo, Florida 33770, United States
Rock Island, Illinois 61201, United States
Kansas City, Kansas 66160, United States
Albuquerque, New Mexico 87106, United States
New York, New York 10065, United States
Hershey, Pennsylvania 17033, United States
Philadelphia, Pennsylvania 19104, United States
Pittsburgh, Pennsylvania 15213, United States
Brentwood, Tennessee 37027, United States
Charlottesville, Virginia 22903, United States
La Louvière, Hainaut 7100, Belgium
Kitchener, Ontario N2M 5N6, Canada
Québec, Quebec G1V 4G5, Canada
Sherbrooke, Quebec J1J 3H5, Canada
Esbjerg, Region Syddanmark 6700, Denmark
Tours, Centre-Val de Loire 37044, France
Marseille, Provence-Alpes-Côte d'Azur Region 13005, France
Frankfurt am Main, Hesse 60590, Germany
Bad Oeynhausen, North Rhine-Westphalia 32545, Germany
Warsaw, Masovian Voivodeship 04-628, Poland
Leicester, Leicestershire LE1 5WW, United Kingdom
Nottingham, Nottinghamshire NG5 1PB, United Kingdom
Oxford, Oxfordshire OX3 9DU, United Kingdom
Coventry, West Midlands CV2 2DX, United Kingdom