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Cognitive disorders are common after intensive care. Currently, their diagnosis is based on clinical tests. The investigators plan to study the relationship between different neurological blood biomarkers (cytokines, S100β protein, neuron specific enolase, total Tau protein and neurofilament light chain) and the occurrence of cognitive disorders during the three months following intensive care discharge.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ICU survivors | Cohort of patients who survive an ICU stay of at least 7 days |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood analysis | Other | Blood analysis for neurological biomarkers measurements |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Blood neurological biomarkers levels | Measurement of blood levels of S100β protein | ICU Admission |
| Blood neurological biomarkers levels | Measurement of blood levels of S100β protein | day 3 after ICU admission |
| Blood neurological biomarkers levels | Measurement of blood levels of S100β protein | day 7 after ICU admission |
| Blood neurological biomarkers levels | Measurement of blood levels of S100β protein | day 14 after ICU admission |
| Blood neurological biomarkers levels | Measurement of blood levels of S100β protein | 3 months after ICU discharge |
| Blood neurological biomarkers levels | Measurement of blood levels of neuron specific enolase | ICU Admission |
| Blood neurological biomarkers levels | Measurement of blood levels of neuron specific enolase | day 3 after ICU admission |
| Blood neurological biomarkers levels | Measurement of blood levels of neuron specific enolase | day 7 after ICU admission |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who survive an ICU stay of at least 7 days and who are assessed 3 months after ICU discharge
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anne-Françoise Rousseau, MD, PhD | Contact | +3243234776 | afrousseau@chuliege.be |
| Name | Affiliation | Role |
|---|---|---|
| Anne-Françoise Rousseau, MD, PhD | University hospital of Liège | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Liège | Recruiting | Liège | 4000 | Belgium |
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| ID | Term |
|---|---|
| C000657744 | postintensive care syndrome |
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D006403 | Hematologic Tests |
| D009483 | Neuropsychological Tests |
| ID | Term |
|---|---|
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
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Blood samples
| Cognitive tests |
| Other |
Questionnaires assessing cognitive function |
|
| Blood neurological biomarkers levels | Measurement of blood levels of neuron specific enolase | day 14 after ICU admission |
| Blood neurological biomarkers levels | Measurement of blood levels of neuron specific enolase | 3 months after ICU discharge |
| Blood neurological biomarkers levels | Measurement of blood levels of total Tau protein | ICU Admission |
| Blood neurological biomarkers levels | Measurement of blood levels of total Tau protein | day 3 after ICU admission |
| Blood neurological biomarkers levels | Measurement of blood levels of total Tau protein | day 7 after ICU admission |
| Blood neurological biomarkers levels | Measurement of blood levels of total Tau protein | day 14 after ICU admission |
| Blood neurological biomarkers levels | Measurement of blood levels of total Tau protein | 3 months after ICU discharge |
| Blood neurological biomarkers levels | Measurement of blood levels of neurofilament light chain | ICU Admission |
| Blood neurological biomarkers levels | Measurement of blood levels of neurofilament light chain | day 3 after ICU admission |
| Blood neurological biomarkers levels | Measurement of blood levels of neurofilament light chain | day 7 after ICU admission |
| Blood neurological biomarkers levels | Measurement of blood levels of neurofilament light chain | day 14 after ICU admission |
| Blood neurological biomarkers levels | Measurement of blood levels of neurofilament light chain | 3 months after ICU discharge |
| Cognitive disorders assessment (global assessment) | Administration of the MOCA questionnaire (Montreal Cognitive Assessment) : scoring from 0 to 30, the highest score meaning the better cognitive outcome) | the day after ICU discharge |
| Cognitive disorders assessment (global assessment) | Administration of the MOCA questionnaire (Montreal Cognitive Assessment) : scoring from 0 to 30, the highest score meaning the better cognitive outcome) | 3 months after ICU discharge |
| Memory disorder assessment | Administration of the California Verbal Learning Test: a Z-score will be used to score this item | 3 months after ICU discharge |
| Memory disorder assessment | Administration of the Brief Visuospatial Memory Test (a Z-score will be used to score this item) | 3 months after ICU discharge |
| Speed of information processing assessment | Administration of the Ways IV test (a Z-score will be used to score this item) | 3 months after ICU discharge |
| Executive function assessment | Administration of the Trail Making Test (a Z-score will be used to score this item) | 3 months after ICU discharge |
| Memory disorder assessment | Administration of the Reading Span (working memory) test (a Z-score will be used to score this item) | 3 months after ICU discharge |
| Executive function assessment | Administration of the Stroop Color and Word Test (a Z-score will be used to score this item) | 3 months after ICU discharge |
| Executive function assessment | Administration of the Go/No-go test (a Z-score will be used to score this item) | 3 months after ICU discharge |
| D011581 | Psychological Tests |
| D004191 | Behavioral Disciplines and Activities |