The purpose of this project is to assess the efficacy of an early neurocognitive intervention for ICU patients, in terms of psychopathological, neuropsychological and functional improvement. The treatment is supported in an interactive advanced computing platform that includes the continuous biomedical registration of the patients and a virtual reality software specifically designed for critical patients.

The investigators expect an improvement in neuropsychological, psychopathological and functional status at hospital discharge and 3 months follow-up in those patients that have received the early neurocognitive intervention comparing with patients treated as usual. Furthermore the investigators expect a decrease of episodes and/or duration of delirium in ICU patients.

Inclusion Criteria:

• Patients aged between 18 and 80 years
• Patients receiving mechanical ventilation for at least 24 hours
• Patients scoring more than 8 on the Glasgow Coma Scale (GCS) and more than 2 on the Sedation Agitation Scale (SAS)
• Patients haemodynamically stable
• Informed consent signed by the closest relatives.

Exclusion Criteria:

• Patients with previous neurologic pathology or focal brain injury before ICU admission
• Patients with serious psychiatric pathology (major depression, psychosis, bipolar disease) or mentally retarded
• Patients with sensorial alterations needed to interact with the neurocognitive stimulation programme
• patients whose closest relatives refuse the subject to be included in the study.