Computer-assisted Cognitive Stimulation Treatment for Delirium

Clinical, Demographic and Genetic Factors Associated With Response to Computer-assisted Cognitive Stimulation Treatment as Part of Non-pharmacological Care in Patients With Delirium. Feasibility Study.

The objectives of our study are to determine whether people with delirium in a subacute care unit improve after one week with non-pharmacological therapies based on improving sleep schedules, mobility, and cognitive stimulation (such as memory, attention, orientation, among others), and to compare two groups of people who will receive slightly different therapies.

We will try to determine whether individual characteristics (such as diagnosed diseases, blood test results or genetics, gender, age, educational level, among others) influence the onset of an episode of delirium, its severity and its response to treatment.

Participants with delirium will be divided into two groups that will receive:

• The non-pharmacological treatment described
• One group will also receive a specific cognitive intervention from an occupational therapist, using a computer programme on a tablet, twice a day for one week.

After one week, the presence and severity of delirium will be reassessed.

Inclusion Criteria:

• All patients aged 60 years or over who are admitted to the subacute care center between 15 February and 15 October 2026 and who sign the informed consent (the patient and their family or legal guardians if the patient's cognitive condition prevents them from giving consent themselves)

Exclusion Criteria:

• Patients who, at the time of admission, meet the criteria for palliative end-of-life care.
• Individuals under 60 years of age, to ensure sample homogeneity and reduce confounding factors.
• Individuals with severe visual or hearing impairment or aphasia, due to the difficulty of carrying out the cognitive intervention.
• Serious communication difficulties due to language.