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Primary Investigator ceased their involvement with study
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| Name | Class |
|---|---|
| Aalborg University Hospital | OTHER |
| Aarhus University Hospital | OTHER |
| Odense University Hospital | OTHER |
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The study will provide information on cognitive impairment and Health related quality of life in patients surviving 12 months after acute brain injury, generate a hypothesis of useful variables to predict cognitive impairment or low levels of HRQoL, and potentially inform interventions for the prevention and treatment of cognitive impairment following neuro-ICU stay.
The aim is to 1) measure the frequency and extent of cognitive impairment after acute brain injury at six and 12-months after neuro-Intensive care unit (ICU) admission 2) explore the association between cognitive impairment at six and 12 months after ICU admission with the following potential risk factors: duration of ICU delirium (days), duration of sepsis (days), duration of post traumatic amnesia (days) and the severity of brain injury (initial Glasgow Coma Scale , 3) describe Health related quality of life, functional disability and frailty at six and 12 after ICU admission and 4) explore the association between the functional disability, frailty and health-related quality of life at 12 months after ICU admission
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| no intervention | Behavioral | no intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Global cognitive function | measured by The Repeatable Battery for the Assessment of Neuropsychological Status, Overall score (mean 100; SD=15). Higher scores indicate better cognitive functioning. | from baseline to 6 months after ICU admission |
| Change in Global cognitive function | measured by The Repeatable Battery for the Assessment of Neuropsychological Status, Overall score (mean 100; SD=15). Higher scores indicate better cognitive functioning. | from baseline to 12 months after ICU admission |
| Change in Executive function | measured by Trail Making Test B, Score indicate time in seconds to complete task, the higher speed (less seconds) indicates higher executive function | from baseline to 6 months after ICU admission |
| Change in Executive function | measured by Trail Making Test B, Score indicate time in seconds to complete task, the higher speed (less seconds) indicates higher executive function | from baseline to 12 months after ICU admission |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Health related quality of life after brain injury | measured with a disease specific questionnaire:Quality of Life after Brain Injury overall scale (QOLIBRI-OS). Scores are from 0-100, the higher the score the more quality of life. | from baseline to 6 months after ICU admission |
| Change in Health related quality of life after brain injury |
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Inclusion Criteria:
Exclusion Criteria:
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Adults with acute brain injury from traumatic brain injury, spontaneous intracranial hemorrhage, or ischemic stroke with a Neuro ICU stay
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| Name | Affiliation | Role |
|---|---|---|
| Suzanne F Herling, Ph.D | Rigshospitalet, Denmark | Principal Investigator |
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| ID | Term |
|---|---|
| D001930 | Brain Injuries |
| D060825 | Cognitive Dysfunction |
| D003693 | Delirium |
| D018805 | Sepsis |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D006259 | Craniocerebral Trauma |
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measured with a disease specific questionnaire:Quality of Life after Brain Injury overall scale (QOLIBRI-OS). Scores are from 0-100, the higher the score the more quality of life. |
| from baseline to 12 months after ICU admission |
| Delirium | measured by Confusion measured by CAM-ICU or Intensive Care Delirium Screening Checklist (ICDSC). | during the procedure (ICU stay) up to 30 days |
| Change in Disability after head injury/nontraumatic acute brain insults I | measured by Glasgow outcome scale extended (GOSE). Scores from 1 to 8, higher scores indicate less disability | from baseline to 6 months after ICU admission |
| Change in Disability after head injury/nontraumatic acute brain insults I | measured by Glasgow outcome scale extended (GOSE). Scores from 1 to 8, higher scores indicate less disability | from baseline to 12 months after ICU admission |
| Change in Disability after head injury/nontraumatic acute brain insults II | measured by Extended disability rating scale (DRS). Scores from 0 to 29, the higher the score the more disability | from baseline to 6 months after ICU admission |
| Change in Disability after head injury/nontraumatic acute brain insults II | measured by Extended disability rating scale (DRS). Scores from 0 to 29, the higher the score the more disability | from baseline to 12 months after ICU admission |
| Change in Frailty | measured by the Clinical Frailty Scale (CFS). Scale is from 1 to 9 ( the higher score the more frail). | baseline to 6 months after ICU admission |
| Change in Frailty | measured by the Clinical Frailty Scale (CFS). Scale is from 1 to 9 ( the higher score the more frail). | baseline to 12 months after ICU admission |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D003221 | Confusion |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |