Development of a Novel Anti-caries Chewing Gum

Development of a Novel Anti-caries Chewing Gum

This research study is designed to evaluate the chewing gum's ability to modulate the oral microbiome in human participants, in addition to its safety.

The goal of this project is to develop a pre-biotic chewing gum that is designed to promote a healthy oral microbiome. The gum will contain compounds that will: a) be unable to be converted to acids; b) target the cariogenic S. mutans population; c) promote the stability of a healthy environment by modulating plaque pH via base-generating compounds; d) promote tooth remineralization by increasing saliva flow and by addition of calcium phosphate.

Inclusion Criteria:

• In good general health, no relevant medical history
• No dental treatment in the previous 3 months
• Willing to participate and give written informed consent

Exclusion Criteria:

• Patients undergoing fixed or removable orthodontic treatment
• Patients using removable prosthesis
• History of head and neck radiation therapy
• History of adverse reaction or allergies to xylitol or other additives
• Antibiotics use in the last four weeks
• Patients with any systemic diseases
• Xerostomia (also medication-induced)
• Smokers
• Currently using any mouth rinse
• Pregnant or breastfeeding women