Xylitol Chewing-gums: Concentration in Saliva and Antibacterial Effect

Xylitol Chewing-gums: Concentration in Saliva and Antibacterial Effect (In-vivo and In-vitro Study)

a double-blind cross-over in vivo study was performed to measure the salivary concentration of Xylitol released from the two chewing gums containing different amount of the polyol. The study had a cross-over design: the first half of the sample used the chewing-gum with Xylitol as the only sweeteners (64.5% of chewing-gum weight) and the other half use the chewing-gum with Xylitol among the sweeteners (22% of chewing-gum weight), after a 7-days wash-out period, the two sub-groups inverted the chewing gums. Subjects were instructed to consume the products as they normally would be consumed.

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Inclusion Criteria:

• good general health,
• the absence of diseases that can alter the saliva secretion rate
• a stimulated saliva flow at least of 1 ml/min.

Exclusion Criteria:

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