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This exploratory study collected basic demographic and laboratory data from the Taiwan Biobank using artificial intelligence algorithms and applied data mining to identify the correlations between phthalate esters [di(2-ethylhexyl) phthalate, DEHP], lifestyle, and disease.
This study was designed as exploratory research. The Institutional Review Board and the Taiwan Biobank approved the study before it was conducted (Approval Number: TWBR11007-06). The data set included information from participants between 30 and 70 years old who were tested for PAEs between 2016 and 2022 (1337 cases). The data set includes (1) questionnaire responses, such as basic personal information, individual health behaviors, and female health issues; (2) physical examination results, such as body mass index (BMI), body fat percentage, waist circumference, hip circumference, waist-to-hip ratio, blood pressure, heart rate, pulmonary function, and bone mineral density; (3) blood and urine analyses results from blood tests, serology tests, hepatobiliary function tests, renal function tests, and urinalysis; and (4) data on PAE content of urine
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| Measure | Description | Time Frame |
|---|---|---|
| Risk assessment analysis of disease and PAEs | (1) questionnaire responses, such as basic personal information, individual health behaviors, and female health issues; (2) physical examination results, such as body mass index (BMI), body fat percentage, waist circumference, hip circumference, waist-to-hip ratio, blood pressure, heart rate, pulmonary function, and bone mineral density; (3) blood and urine analyses results from blood tests, serology tests, hepatobiliary function tests, renal function tests, and urinalysis; and (4) data on PAE content of urine. | 2022 |
| Artificial intelligence prediction model for diseases and PAEs | to apply machine learning to establish the correlations between the environmental hormone PAE and high disease risk and suggest assessment items for nursing intervention. | 2022 |
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inclusion:
exclusion:
1who have not been tested for plasticizers
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The study included 1337 subjects, with an average age of 48.98 years. Male subjects (51.8%) outnumbered the females. In addition, 75.1% of the subjects were married, 9.4% had drinking habits, 57.4% did not exercise regularly, 15.3% worked in the manufacturing industry, 47.4% were overweight according to BMI, 45.2% had a body fat percentage higher than normal, and 16.8% had bone density below 2.5. Table 1 shows the analysis results.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cheng Hsin General Hospital | Taipei | Taiwan | ||||
| National Taipei university of nursing and health science |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39736874 | Derived | Wu HT, Liao CC, Peng CF, Lee TY, Liao PH. Exploring the application of machine learning to identify the correlations between phthalate esters and disease: enhancing nursing assessments. Health Inf Sci Syst. 2024 Dec 29;13(1):10. doi: 10.1007/s13755-024-00324-4. eCollection 2025 Dec. |
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| Taipei |
| Taiwan |